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[The pharmacokinetics of azlocillin after single and multiple intravenous injections during the third trimester].
- Source :
-
Zentralblatt fur Gynakologie [Zentralbl Gynakol] 1988; Vol. 110 (15), pp. 944-8. - Publication Year :
- 1988
-
Abstract
- Examining serum level values and urinary concentrations taken from non-pregnant control persons and pregnant women suffering from urinary tract infections (UTI) during the III. trimenon, the pharmacokinetic dates after single and repeated applications of 4 g azlocillin have been evaluated. We used a computer program based on the two-compartment model. It is shown that during pregnancy complicated by UTI the elimination half-life time will be prolonged and returns after therapy nearly to normal values. The results, discussed with the dates given by literature, allow us to state that it is not necessary to change dosage and application interval of azlocillin during pregnancy.
- Subjects :
- Adult
Azlocillin administration & dosage
Azlocillin metabolism
Drug Administration Schedule
Female
Half-Life
Humans
Injections, Intravenous
Metabolic Clearance Rate
Pregnancy
Pregnancy Trimester, Third
Azlocillin pharmacokinetics
Pregnancy Complications, Infectious metabolism
Urinary Tract Infections metabolism
Subjects
Details
- Language :
- German
- ISSN :
- 0044-4197
- Volume :
- 110
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Zentralblatt fur Gynakologie
- Publication Type :
- Academic Journal
- Accession number :
- 3055753