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HLA epitope mismatch in haploidentical transplantation is associated with decreased relapse and delayed engraftment.
- Source :
-
Blood advances [Blood Adv] 2018 Dec 26; Vol. 2 (24), pp. 3590-3601. - Publication Year :
- 2018
-
Abstract
- HLA disparity is traditionally measured at the antigen or allele level, and its impact on haploidentical hematopoietic cell transplantation (haplo-HCT) with high-dose posttransplant cyclophosphamide (PTCy) is unclear. To the best of our knowledge, the relationship between HLA eplet-derived epitope mismatch (EM) and clinical outcome has not been examined in haplo-HCT. We retrospectively analyzed 148 patients who received a peripheral blood, T-cell-replete haplo-HCT with PTCy at a single center. HLA EM was quantified using an HLAMatchmaker-based method and was stratified by class and vector. The primary outcome was incidence of relapse. The total number of mismatched epitopes (MEs) per patient-donor pair in our patient population ranged from 0 to 51 (median, 24) in the graft-versus-host (GVH) direction and 0 to 47 (median, 24) in the host-versus-graft (HVG) direction. Higher HLA class II EM in the GVH direction was associated with a significantly reduced risk of relapse (adjusted hazard ratio [HR], 0.952 per ME; P = .002) and improved relapse-free survival (adjusted HR, 0.974 per ME; P = .020). Higher HLA class II EM in the HVG direction was associated with longer time to neutrophil (adjusted HR, 0.974 per ME; P = .013) and platelet (adjusted HR, 0.961 per ME; P = .001) engraftment. In peripheral blood haplo-HCT patients, increased HLA EM was associated with a protective effect on the risk of relapse in the GVH direction but a negative effect on time to count recovery in the HVG direction. HLA EM based on the HLA Matchmaker represents a novel strategy to predict clinical outcome in haplo-HCT.<br /> (© 2018 by The American Society of Hematology.)
- Subjects :
- Adult
Aged
Epitopes immunology
Female
Graft Survival
Graft vs Host Disease etiology
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Leukemia mortality
Male
Middle Aged
Proportional Hazards Models
Recurrence
Retrospective Studies
Transplantation, Haploidentical adverse effects
Young Adult
HLA Antigens immunology
Leukemia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2473-9537
- Volume :
- 2
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Blood advances
- Publication Type :
- Academic Journal
- Accession number :
- 30563883
- Full Text :
- https://doi.org/10.1182/bloodadvances.2018025437