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A diagnostic strategy for breast calcifications based on a long-term follow-up of 615 lesions.

Authors :
Yonekura R
Horii R
Iwase T
Gomi N
Kitagawa M
Akiyama F
Ohno S
Source :
Japanese journal of radiology [Jpn J Radiol] 2019 Mar; Vol. 37 (3), pp. 237-244. Date of Electronic Publication: 2018 Dec 19.
Publication Year :
2019

Abstract

Purpose: To clarify the long-term outcomes of breast calcifications after stereotactic vacuum-assisted breast biopsy (SVAB) and to develop strategy after SVAB.<br />Methods: Subject comprised 594 patients with 615 calcifications who underwent SVAB. 371 (60.3%) lesions were diagnosed as benign, 38 (6.2%) as indeterminate, and 206 (33.5%) as malignant. We retrospectively reviewed post-biopsy courses of non-malignant lesions which were followed. A histopathological review was performed for false negatives to clarify the reasons.<br />Results: Of the 308 patients with benign lesions, with a median follow-up time of 55.8 months, re-biopsy was performed for 11 (3.6%) due to changes of imaging, and 4 (1.3%) were diagnosed as breast cancer. Of the 36 patients with indeterminate lesion, re-biopsy was performed for 16 (44.4%), and 8 (22.2%) were diagnosed as breast cancer, while 20 (55.6%) showed no changes in imaging with a median follow-up time of 91.7 months without re-biopsy. Weak atypism of intraductal carcinoma may cause a false-negative diagnosis in SVAB for breast calcifications.<br />Conclusions: When SVAB results in non-malignant, patients may be followed by annual screening, while re-biopsy needs to be performed for the patients with a discordant result of SVAB and with changes in an imaging finding during a follow-up.

Details

Language :
English
ISSN :
1867-108X
Volume :
37
Issue :
3
Database :
MEDLINE
Journal :
Japanese journal of radiology
Publication Type :
Academic Journal
Accession number :
30569402
Full Text :
https://doi.org/10.1007/s11604-018-0803-7