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Smart Metal-Organic Framework-Based Nanoplatforms for Imaging-Guided Precise Chemotherapy.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2019 Jan 16; Vol. 11 (2), pp. 1886-1895. Date of Electronic Publication: 2019 Jan 04. - Publication Year :
- 2019
-
Abstract
- Good biocompatibility, active tumor targeting, and stimulus-responsive release offer great opportunity for precise imaging-guided tumor treatment. However, the current strategies for the fabrication of smart theranostic platforms suffer from tedious synthesis processes. Here, we propose a universal and facile strategy for the fabrication of smart nanoscale metal-organic framework (NMOF)-based nanoplatforms for imaging-guided precise chemotherapy. As a proof of concept, 5-boronobenzene-1,3-dicarboxylic acid (BBDC), as a versatile ligand, was employed for the first time with Gd <superscript>3+</superscript> as metal nodes to prepare a smart magnetic resonance (MR) imaging-guided drug-delivery system. Specific reversible diol-borate condensation enables effortless coating of glucose on the NMOFs to improve their biocompatibility. The specific interaction between glucose and glucose-transported protein ensures active tumor-targeting ability. Moreover, the glucose layer, as a pH-responsive diol-borate gatekeeper, prevents the premature leakage of drugs. The proposed smart theranostic nanoplatform was well used in MR imaging-guided tumor-targeted precise chemotherapy. This strategy is simply extended to the design of other MOF-glucose composites for diverse applications, such as X-ray computed tomography imaging of gastrointestinal tract with Yb-MOFs-Glu. BBDC, as a functional ligand, provides a simple and universal way to fabricate smart NMOF theranostic platforms with multifunction as "three birds with one stone". The facile and universal strategy lays down a new way to develop multifunctional nanoagents for precision medicine.
- Subjects :
- Animals
Gadolinium chemistry
Gadolinium pharmacology
HeLa Cells
Humans
Mice
Contrast Media chemical synthesis
Contrast Media chemistry
Contrast Media pharmacology
Doxorubicin chemistry
Doxorubicin pharmacology
Drug Delivery Systems
Magnetic Resonance Imaging
Metal-Organic Frameworks chemical synthesis
Metal-Organic Frameworks chemistry
Metal-Organic Frameworks pharmacology
Neoplasms, Experimental diagnostic imaging
Neoplasms, Experimental drug therapy
Neoplasms, Experimental metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 30584757
- Full Text :
- https://doi.org/10.1021/acsami.8b19048