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Prognostic Value of Red Blood Cell Distribution Width in Non-small Cell Lung Cancer Treated With Anti-programmed Cell Death-1 Antibody.
- Source :
-
In vivo (Athens, Greece) [In Vivo] 2019 Jan-Feb; Vol. 33 (1), pp. 213-220. - Publication Year :
- 2019
-
Abstract
- Background/aim: Red cell distribution width (RDW) has been reported to reflect the inflammation and nutrition status and predict prognosis of non-small cell lung cancer (NSCLC) patients treated with anti-programmed cell death-1 (PD-1) antibody. The aim of this study was to analyze the correlation between RDW and prognosis of NSCLC patients.<br />Patients and Methods: We collected retrospective data on consecutive NSCLC patients treated with anti-PD-1 antibody from December 2015 to April 2018 at the Kobe University Hospital, Japan.<br />Results: Forty-seven patients were treated. Patients with RDW ≥16% had a significantly shorter OS (p=0.010) compared to those with RDW <16%. In multivariate analysis, RDW ≥16% was an independent factor predicting poor prognosis (p=0.019).<br />Conclusion: Pre-treatment RDW ≥16% is an indicator of poor prognosis. RDW is an inexpensive, convenient, and routinely available marker of prognosis.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung immunology
Carcinoma, Non-Small-Cell Lung pathology
Disease-Free Survival
Female
Humans
Male
Middle Aged
Prognosis
Programmed Cell Death 1 Receptor immunology
Retrospective Studies
Antibodies, Anti-Idiotypic administration & dosage
Carcinoma, Non-Small-Cell Lung blood
Carcinoma, Non-Small-Cell Lung drug therapy
Erythrocytes
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7549
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- In vivo (Athens, Greece)
- Publication Type :
- Academic Journal
- Accession number :
- 30587626
- Full Text :
- https://doi.org/10.21873/invivo.11462