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Folate and vitamin B 12 status and their relation to hematological indices in healthy adults of Iranians: Azar cohort study.
- Source :
-
Nutrition and health [Nutr Health] 2019 Mar; Vol. 25 (1), pp. 29-36. Date of Electronic Publication: 2018 Dec 28. - Publication Year :
- 2019
-
Abstract
- Background:: Folate and vitamin B <subscript>12</subscript> are essential micronutrients, the deficiency of which can be associated with public health problems worldwide.<br />Aim:: The aims of this study were to assess the folate and vitamin B <subscript>12</subscript> status of healthy adults and the effect of gender differences on their deficiency using serum folate, vitamin B <subscript>12</subscript> and red blood cell (RBC) folate as biomarkers and their relation to hematological indices.<br />Methods:: This study was a part of the Azar cohort study, which is designed as a noncommunicable disease survey in the population of Shabestar, East Azerbaijan, Iran. A total of 95 healthy adults (35 men, 60 women) were chosen according to exclusion criteria and assessed using demographic characteristics and blood sampling.<br />Results:: Low concentrations of serum folate, vitamin B <subscript>12</subscript> and RBC folate were detected in 16.8%, 61.1% and 40% of all subjects, respectively. Prevalence of low serum folate and vitamin B <subscript>12</subscript> was higher in men than women (25.7% versus 11.7% for serum folate, 77.1% versus 51.7% for serum vitamin B <subscript>12</subscript> ).A significant positive correlation was found between hemoglobin and serum folate, vitamin B <subscript>12</subscript> and RBC folate concentrations ( r = 0.279, 0.335, 0.228, respectively). No statistically significant correlation between mean corpuscular volume and serum folate, vitamin B <subscript>12</subscript> and RBC folate was seen ( r = -0.049, -0.030, -0.016, respectively).<br />Conclusions:: There was a high prevalence of low folate and vitamin B <subscript>12</subscript> concentrations in our community. Regarding the impact of these two vitamins deficiency on overall health, we suggest further investigations with more participants. In addition, monitoring hematological indices could be useful in people with folate and vitamin B <subscript>12</subscript> deficiency.
- Subjects :
- Adult
Age Factors
Cohort Studies
Erythrocyte Indices
Erythrocytes metabolism
Female
Folic Acid Deficiency blood
Hematology
Humans
Iran
Male
Middle Aged
Prevalence
Sex Factors
Surveys and Questionnaires
Vitamin B 12 Deficiency blood
Folic Acid blood
Folic Acid Deficiency epidemiology
Hemoglobins metabolism
Nutritional Status
Vitamin B 12 blood
Vitamin B 12 Deficiency epidemiology
Vitamin B Complex blood
Subjects
Details
- Language :
- English
- ISSN :
- 0260-1060
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrition and health
- Publication Type :
- Academic Journal
- Accession number :
- 30590987
- Full Text :
- https://doi.org/10.1177/0260106018815392