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Anticoagulant Therapy for Disseminated Intravascular Coagulation After Gastrointestinal Surgery.
- Source :
-
Anticancer research [Anticancer Res] 2019 Jan; Vol. 39 (1), pp. 25-31. - Publication Year :
- 2019
-
Abstract
- Many studies about anticoagulant therapy for disseminated intravascular coagulation (DIC) confused gastrointestinal surgery-related DIC with DIC unrelated to a prior operation. Furthermore, the potentially increased risk of bleeding by anticoagulants complicates their use. We carried out a systematic review to describe the efficacy and safety of anticoagulant agents for DIC after gastrointestinal surgery. Several studies have indicated that gabexate mesylate improves DIC score without increasing bleeding events, and that antithrombin is associated with lower mortality of DIC after gastrointestinal surgery. Recombinant thrombomodulin has been the most frequently analyzed anticoagulant agent in this field. DIC score and survival rate were better in patients treated with recombinant thrombomodulin, without increasing bleeding events. In conclusion, anticoagulant therapy may be effective and safe in DIC after gastrointestinal surgery.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Disseminated Intravascular Coagulation chemically induced
Disseminated Intravascular Coagulation physiopathology
Gabexate therapeutic use
Hemorrhage chemically induced
Hemorrhage physiopathology
Humans
Thrombomodulin therapeutic use
Anticoagulants adverse effects
Digestive System Surgical Procedures adverse effects
Disseminated Intravascular Coagulation drug therapy
Hemorrhage drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 39
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 30591437
- Full Text :
- https://doi.org/10.21873/anticanres.13076