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Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis.

Authors :: Nissinen SI
Roine A
Hokkinen L
Karjalainen M
Venäläinen M
Helminen H
Niemi R
Lehtimäki T
Rantanen T
Oksala N
Source :: Anticancer research [Anticancer Res] 2019 Jan; Vol. 39 (1), pp. 73-79.
Publication Year :: 2019
Abstract: Background/aim: Most pancreatic cancer patients are diagnosed at an advanced stage, since the diagnosis is demanding. Field asymmetric waveform ion mobility spectrometry (FAIMS) is a sensitive technique used for the detection of volatile organic compounds (VOC). We evaluated the ability of FAIMS to discriminate between pancreatic cancer and healthy controls from a urine sample.<br />Patients and Methods: For a proof-of-concept study in three Finnish hospitals, 68 patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis, 8 with pancreatic pre-malign lesions and 52 healthy controls were prospectively recruited. Urine samples were collected at the time of diagnosis and stored at -70°C. The samples were subsequently measured with FAIMS. The data were processed with linear discriminant analysis and cross-validated with leave-one-out cross-validation.<br />Results: FAIMS distinguished pancreatic cancer from controls with a sensitivity of 79% and specificity of 79%.<br />Conclusion: As a non-invasive and rapid urine test, FAIMS can discriminate patients with pancreatic cancer from healthy controls.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)