Back to Search
Start Over
Long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
- Source :
-
Head & neck [Head Neck] 2019 May; Vol. 41 (5), pp. 1246-1252. Date of Electronic Publication: 2018 Dec 28. - Publication Year :
- 2019
-
Abstract
- Purpose: To analyze the long-term outcome and pattern of failure for patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT).<br />Methods and Materials: Patients with NPC after IMRT from 2001 to 2008 were recruited (n = 865). Clinical features, laboratory data, and treatments were collected.<br />Results: The 10-year local recurrence-free survival, distant metastasis-free survival, and disease-specific survival (DSS) were 92.0%, 83.4%, and 78.6%, respectively. A total of 209 patients died: 59% of whom died from distant metastasis. The 10-year DSS was higher in patients who received chemoradiotherapy than those who received IMRT alone for patients with high-risk stage III disease, while there was no survival difference for patients with stage II and low-risk stage III disease.<br />Conclusions: IMRT provides satisfactory long-term survival for patients with NPC. Distant metastasis has been the most common reason for failure. Adding chemotherapy did not improve survival in patients with stage II and low-risk stage III disease.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Adolescent
Adult
Aged
Analysis of Variance
Chemoradiotherapy
Female
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma drug therapy
Nasopharyngeal Carcinoma mortality
Nasopharyngeal Carcinoma secondary
Nasopharyngeal Neoplasms drug therapy
Nasopharyngeal Neoplasms mortality
Nasopharyngeal Neoplasms pathology
Neoplasm Staging
Survival Analysis
Treatment Failure
Treatment Outcome
Young Adult
Nasopharyngeal Carcinoma radiotherapy
Nasopharyngeal Neoplasms radiotherapy
Radiotherapy, Intensity-Modulated
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 41
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 30593728
- Full Text :
- https://doi.org/10.1002/hed.25545