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L’immunothérapie dans les cancers ORL.
- Source :
-
Bulletin du cancer [Bull Cancer] 2018 Dec; Vol. 105 Suppl 1, pp. S35-S42. - Publication Year :
- 2018
-
Abstract
- Immunotherapy in Head and Neck Cancers: Immunotherapy wave has also touched head and neck cancer. In recurrent or metastatic disease, checkpoint inhibitors (anti PD-1/PD-L1) are approved in 2 <superscript>nd</superscript> line with a clear benefit on overall survival and quality of life. Multiple clinical studies are in progress in both palliative and curative intent, combined or not with other checkpoint inhibitor (anti-CTLA4) or other standard therapies (radiotherapy, chemotherapy). It is essential to define which patients will benefit from immunotherapy, according to robust biomarkers, in order to increase risk benefit balance by decreasing side effects and selecting those who respond the most. Here we present an overview of immunotherapy in 2018 in head and neck squamous cell cancer.<br /> (© 2018 Société Française du Cancer. Publié par Elsevier Masson SAS. Tous droits réservés.)
- Subjects :
- Antibodies, Monoclonal, Humanized therapeutic use
Antineoplastic Agents, Immunological therapeutic use
Combined Modality Therapy methods
Head and Neck Neoplasms mortality
Humans
Nivolumab therapeutic use
B7-H1 Antigen antagonists & inhibitors
CTLA-4 Antigen antagonists & inhibitors
Head and Neck Neoplasms therapy
Immunotherapy
Programmed Cell Death 1 Receptor antagonists & inhibitors
Subjects
Details
- Language :
- French
- ISSN :
- 1769-6917
- Volume :
- 105 Suppl 1
- Database :
- MEDLINE
- Journal :
- Bulletin du cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30595197
- Full Text :
- https://doi.org/10.1016/S0007-4551(18)30388-6