Back to Search Start Over

Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression.

Authors :
Salloum NC
Fava M
Freeman MP
Flynn M
Hoeppner B
Hock RS
Cusin C
Iosifescu DV
Trivedi MH
Sanacora G
Mathew SJ
Debattista C
Ionescu DF
Papakostas GI
Source :
Depression and anxiety [Depress Anxiety] 2019 Mar; Vol. 36 (3), pp. 235-243. Date of Electronic Publication: 2018 Dec 30.
Publication Year :
2019

Abstract

Objective: To examine the effect of high baseline anxiety on response to ketamine versus midazolam (active placebo) in treatment-resistant depression (TRD).<br />Methods: In a multisite, double-blind, placebo-controlled trial, 99 subjects with TRD were randomized to one of five arms: a single dose of intravenous ketamine 0.1, 0.2, 0.5, 1.0 mg/kg, or midazolam 0.045 mg/kg. The primary outcome measure was change in the six-item Hamilton Rating Scale for Depression (HAMD6). A linear mixed effects model was used to examine the effect of anxious depression baseline status (defined by a Hamilton Depression Rating Scale Anxiety-Somatization score ≥7) on response to ketamine versus midazolam at 1 and 3 days postinfusion.<br />Results: N = 45 subjects had anxious TRD, compared to N = 54 subjects without high anxiety at baseline. No statistically significant interaction effect was found between treatment group assignment (combined ketamine treatment groups versus midazolam) and anxious/nonanxious status on HAMD6 score at either days 1 or 3 postinfusion (Day 1: F(1, 84) = 0.02, P = 0.88; Day 3: F(1, 82) = 0.12, P = 0.73).<br />Conclusion: In contrast with what is observed with traditional antidepressants, response to ketamine may be similar in both anxious and nonanxious TRD subjects. These pilot results suggest the potential utility of ketamine in the treatment of anxious TRD.<br /> (© 2018 Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1520-6394
Volume :
36
Issue :
3
Database :
MEDLINE
Journal :
Depression and anxiety
Publication Type :
Academic Journal
Accession number :
30597688
Full Text :
https://doi.org/10.1002/da.22875