Back to Search
Start Over
Efficacy of intravenous ketamine treatment in anxious versus nonanxious unipolar treatment-resistant depression.
- Source :
-
Depression and anxiety [Depress Anxiety] 2019 Mar; Vol. 36 (3), pp. 235-243. Date of Electronic Publication: 2018 Dec 30. - Publication Year :
- 2019
-
Abstract
- Objective: To examine the effect of high baseline anxiety on response to ketamine versus midazolam (active placebo) in treatment-resistant depression (TRD).<br />Methods: In a multisite, double-blind, placebo-controlled trial, 99 subjects with TRD were randomized to one of five arms: a single dose of intravenous ketamine 0.1, 0.2, 0.5, 1.0 mg/kg, or midazolam 0.045 mg/kg. The primary outcome measure was change in the six-item Hamilton Rating Scale for Depression (HAMD6). A linear mixed effects model was used to examine the effect of anxious depression baseline status (defined by a Hamilton Depression Rating Scale Anxiety-Somatization score ≥7) on response to ketamine versus midazolam at 1 and 3 days postinfusion.<br />Results: N = 45 subjects had anxious TRD, compared to N = 54 subjects without high anxiety at baseline. No statistically significant interaction effect was found between treatment group assignment (combined ketamine treatment groups versus midazolam) and anxious/nonanxious status on HAMD6 score at either days 1 or 3 postinfusion (Day 1: F(1, 84) = 0.02, P = 0.88; Day 3: F(1, 82) = 0.12, P = 0.73).<br />Conclusion: In contrast with what is observed with traditional antidepressants, response to ketamine may be similar in both anxious and nonanxious TRD subjects. These pilot results suggest the potential utility of ketamine in the treatment of anxious TRD.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Depressive Disorder, Major complications
Depressive Disorder, Major drug therapy
Double-Blind Method
Female
Humans
Male
Midazolam therapeutic use
Middle Aged
Treatment Outcome
Anxiety complications
Anxiety Disorders complications
Depressive Disorder, Treatment-Resistant complications
Depressive Disorder, Treatment-Resistant drug therapy
Ketamine administration & dosage
Ketamine therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6394
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Depression and anxiety
- Publication Type :
- Academic Journal
- Accession number :
- 30597688
- Full Text :
- https://doi.org/10.1002/da.22875