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Is there association of gross tumor volume of adenocarcinoma of oesophagogastric junction measured on magnetic resonance imaging with N stage?
- Source :
-
European journal of radiology [Eur J Radiol] 2019 Jan; Vol. 110, pp. 181-186. Date of Electronic Publication: 2018 May 22. - Publication Year :
- 2019
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Abstract
- Purpose: To determine whether gross tumour volume (GTV) of adenocarcinoma of oesophagogastric junction (AOG) measured on fat-suppression T <subscript>2</subscript> -weighted imaging (FS-T <subscript>2</subscript> WI) and diffusion-weighted imaging (DWI) correlates with regional lymph node metastasis and N stage.<br />Materials and Methods: The study was approved by the institutional ethics committee, and written informed consent was obtained. Forty-six patients with AOG underwent preoperative magnetic resonance scans including FS-T <subscript>2</subscript> WI and DWI with b-values of 500 and 800 s/mm <superscript>2</superscript> . GTV was measured on FS-T <subscript>2</subscript> WI and DWI. Statistical analyses were performed to determine association of GTV with N stage.<br />Results: Univariate analysis showed GTV measured on FS-T <subscript>2</subscript> WI and DWI with b-values of 500 and 800 s/mm <superscript>2</superscript> were correlated with lymph node metastasis (all Ps < 0.05). Spearman rank correlation tests demonstrated a trend toward an increase in GTV obtained on previous sequences with increasing N stage (r = 0.578 to 0.591, all Ps < 0.001). Mann-Whitney U tests showed GTV obtained on previous sequences could distinguish grouped N stages (all Ps < 0.05). Receiver operating curve analyses demonstrated that GTV obtained on FS-T <subscript>2</subscript> WI and DWI with b-value of 500 s/mm <superscript>2</superscript> and DWI with b-value of 800 s/mm <superscript>2</superscript> might differentiate stage N0 from stages N1-3 (cutoff, 19.70 cm <superscript>3</superscript> , 16.70 cm <superscript>3</superscript> and 12.24 cm <superscript>3</superscript> , respectively), stages N0-1 from N2-3 (cutoff: 22.16 cm <superscript>3</superscript> , 17.54 cm <superscript>3</superscript> and 14.17 cm <superscript>3</superscript> , respectively), stages N0-2 from N3 (cutoff: 25.57 cm <superscript>3</superscript> , 29.27 cm <superscript>3</superscript> and 22.73 cm <superscript>3</superscript> , respectively).<br />Conclusion: There is a trend toward an increase in GTV obtained on FS-T <subscript>2</subscript> WI and DWI sequences with increasing N stage.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Aged
Diffusion Magnetic Resonance Imaging methods
Esophagogastric Junction diagnostic imaging
Esophagogastric Junction pathology
Female
Humans
Male
Middle Aged
Neoplasm Staging
Reproducibility of Results
Adenocarcinoma diagnostic imaging
Adenocarcinoma pathology
Esophageal Neoplasms diagnostic imaging
Esophageal Neoplasms pathology
Magnetic Resonance Imaging methods
Tumor Burden
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7727
- Volume :
- 110
- Database :
- MEDLINE
- Journal :
- European journal of radiology
- Publication Type :
- Academic Journal
- Accession number :
- 30599858
- Full Text :
- https://doi.org/10.1016/j.ejrad.2018.05.023