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Suprasellar chordoid glioma: a report of two cases.
- Source :
-
Archives of endocrinology and metabolism [Arch Endocrinol Metab] 2018; Vol. 62 (6), pp. 648-654. - Publication Year :
- 2018
-
Abstract
- Chordoid glioma (CG) is considered a slow growing glial neoplasm. We report two new cases with endocrinological presentation, management and outcome. Case reports: 1) An 18 year-old female patient was admitted due to headaches, nausea and vomiting and visual abnormalities. She was in amenorrhea. A brain magnetic resonance imaging (MRI) demonstrated a 35 mm-diameter sellar and suprasellar mass. An emergency ventricular peritoneal valve was placed due to obstructive hydrocephalus. Transcraneal surgery was performed. The patient developed central hypothyroidism, adrenal insufficiency and transient diabetes insipidus; she never recovered spontaneous menstrual cycles. Histopathologic study showed cells in cords, inside a mucinous stroma, positive for glial fibrillary acidic protein (GFAP). Due to residual tumor gamma knife radiosurgery was performed. Three years after surgery, the patient is lucid, with hypopituitarism under replacement. 2) A 46 year-old woman complained about a three year-history of amenorrhea, galactorrhea and headache. An MRI showed a solid-cystic sellar mass 40 mm-diameter that extended to the suprasellar cistern. She had hypogonatropic hypogonadism and mild hyperprolactinemia. The tumor mass was removed via nasal endoscopic approach. Histopathological study reported cellular proliferation of glial lineage positive for GFAP. The patient evolved with central hypothyroidism and diabetes insipidus. She was re-operated for fistula and again under the diagnosis of extradural abscess. She evolved with cardiorespiratory descompensation and death, suspected to be due to a thromboembolism. In conclusion, the first case confirms that best treatment for CG is surgery considering radiotherapy as an adjuvant therapy. The other case, on the contrary, illustrates the potentially fatal evolution due to surgical complications.
- Subjects :
- Adolescent
Biopsy
Brain Neoplasms diagnostic imaging
Brain Neoplasms surgery
Fatal Outcome
Female
Glioma diagnostic imaging
Glioma surgery
Humans
Magnetic Resonance Imaging
Middle Aged
Sella Turcica
Third Ventricle diagnostic imaging
Third Ventricle surgery
Treatment Outcome
Brain Neoplasms pathology
Glioma pathology
Third Ventricle pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2359-4292
- Volume :
- 62
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Archives of endocrinology and metabolism
- Publication Type :
- Report
- Accession number :
- 30624507
- Full Text :
- https://doi.org/10.20945/2359-3997000000092