Back to Search
Start Over
Hepatic Injury without Granulomatous Formation Associated with Intravesical Bacillus Calmette-Guérin Therapy.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2019 May 15; Vol. 58 (10), pp. 1429-1432. Date of Electronic Publication: 2019 Jan 10. - Publication Year :
- 2019
-
Abstract
- A 74-year-old man developed hepatic injury after intravesical Bacillus Calmette-Guérin (BCG) therapy for bladder carcinoma. Although hepatitis-associated disseminated BCG was suspected, granulomatous formations were undetectable. The hepatic injury was considered to have resulted from an allergic reaction to BCG therapy because a histopathological assessment revealed enlarged portal areas with eosinophils and neutrophils. The hepatic injury was resolved by prednisolone. This case suggested that hepatic injury associated with BCG therapy might be due to an allergic mechanism unrelated to disseminated BCG disease. A liver biopsy is needed to confirm the histopathological findings of hepatic injury after BCG therapy in order to differentiate allergic hepatic injury from infectious hepatic injury.
- Subjects :
- Administration, Intravesical
Aged
Hepatitis etiology
Humans
Male
Treatment Outcome
BCG Vaccine therapeutic use
Hepatitis drug therapy
Hypersensitivity drug therapy
Hypersensitivity etiology
Liver physiopathology
Prednisolone therapeutic use
Urinary Bladder Neoplasms complications
Urinary Bladder Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 58
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 30626835
- Full Text :
- https://doi.org/10.2169/internalmedicine.2073-18