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Association Between Brain β-Amyloid and Frailty in Older Adults.
- Source :
-
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2019 Oct 04; Vol. 74 (11), pp. 1747-1752. - Publication Year :
- 2019
-
Abstract
- Background: We sought to determine whether cortical and regional β-amyloid (Aβ) were cross-sectionally and prospectively associated with change in frailty status in older adults.<br />Methods: We used data from 269 community-dwelling participants from the Multidomain Alzheimer's Preventive Trial (MAPT) who were assessed for brain Aβ using positron-emission tomography scan. Regional and cortical-to-cerebellar standardized uptake value ratios were obtained. Frailty was assessed by a frailty index composed of 19 items not directly linked to cognition and Alzheimer's disease.<br />Results: A significant and positive cross-sectional and prospective relationship was found for Aβ in the anterior putamen (cross-sectional: β = 0.11 [0.02-0.20], p = .02; prospective: β = 0.11 [0.03-0.19], p = .007), posterior putamen (cross-sectional: β = 0.12 [0.009-0.23], p = .03; prospective: β = 0.11 [0.02-0.21], p = .02), and precuneus regions (cross-sectional: β = 0.07 [0.01-0.12], p = .01; prospective: β = 0.07 [0.01-0.12], p = .01) with increasing frailty.<br />Conclusions: This study has found new information regarding cross-sectional and prospective positive associations between region-specific brain Aβ deposits and worsening frailty. The potential mechanisms involved require further investigation.<br /> (© The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- Aged
Aged, 80 and over
Alzheimer Disease diagnostic imaging
Biomarkers metabolism
Brain metabolism
Cross-Sectional Studies
Disease Progression
Female
Follow-Up Studies
Frailty diagnostic imaging
Humans
Independent Living
Linear Models
Male
Multivariate Analysis
Prospective Studies
Severity of Illness Index
Aging metabolism
Alzheimer Disease metabolism
Amyloid beta-Peptides analysis
Frailty metabolism
Positron-Emission Tomography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1758-535X
- Volume :
- 74
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 30629123
- Full Text :
- https://doi.org/10.1093/gerona/glz009