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Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.
- Source :
-
Journal of epidemiology [J Epidemiol] 2019 Dec 05; Vol. 29 (12), pp. 478-486. Date of Electronic Publication: 2019 Jan 12. - Publication Year :
- 2019
-
Abstract
- Background: Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.<br />Methods: We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ≥0.35 UA/mL, and the metal levels were divided into quartiles.<br />Results: Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.<br />Conclusions: Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.
- Subjects :
- Adult
Female
Humans
Japan
Pregnancy
Immunoglobulin E blood
Metals blood
Subjects
Details
- Language :
- English
- ISSN :
- 1349-9092
- Volume :
- 29
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 30643099
- Full Text :
- https://doi.org/10.2188/jea.JE20180098