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Assessing Microcirculation in Resectable Oesophageal Squamous Cell Carcinoma with Dynamic Contrast-enhanced MRI for Identifying Primary tumour and Lymphatic Metastasis.
- Source :
-
Scientific reports [Sci Rep] 2019 Jan 15; Vol. 9 (1), pp. 124. Date of Electronic Publication: 2019 Jan 15. - Publication Year :
- 2019
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Abstract
- This study aimed to determine whether dynamic contrast-enhanced MRI (DCE-MRI) derived parameters can identify oesophageal squamous cell carcinoma (SCC) and lymphatic metastasis. Thirty-nine oesophageal SCC patients underwent DCE-MRI. Quantitative parameters including endothelial transfer constant (K <superscript>trans</superscript> ), reflux rate (K <subscript>ep</subscript> ), fractional extravascular extracellular space volume and fractional plasma volume, and semi-quantitative parameters including time to peak (TTP), max concentration, Max Slope and area under concentration-time curve of both oesophageal SCC and normal oesophagus were measured. Mann-Whitney U test revealed that K <superscript>trans</superscript> and K <subscript>ep</subscript> of oesophageal SCC were higher while TTP was shorter when compared to normal oesophagus (all P-values < 0.05); and areas under receiver operating characteristic [ROC] curves displayed that K <subscript>ep</subscript> was superior to TTP or K <superscript>trans</superscript> for identifying oesophageal SCC (0.903 vs. 0.832 or 0.713). Mann-Whitney U test also demonstrated that K <subscript>ep</subscript> was higher and TTP was shorter in patients with lymphatic metastasis when compared to non-metastatic cancer patients (both P-values < 0.05), and area under ROC curve also showed that TTP was superior to K <subscript>ep</subscript> for predicting lymphatic metastasis (0.696 vs. 0.659). In conclusion, the combination of quantitative and semi-quantitative parameters derived from DCE-MRI can aid in the identification of oesophageal SCC and lymphatic metastasis.
- Subjects :
- Aged
Contrast Media standards
Esophageal Squamous Cell Carcinoma blood supply
Esophageal Squamous Cell Carcinoma pathology
Female
Humans
Male
Middle Aged
Neoplasm Metastasis diagnostic imaging
ROC Curve
Esophageal Squamous Cell Carcinoma diagnostic imaging
Lymphatic Metastasis diagnostic imaging
Magnetic Resonance Imaging methods
Microcirculation
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30644415
- Full Text :
- https://doi.org/10.1038/s41598-018-36929-5