The SPECTRA Collaboration OMERACT Working Group: Construct Validity of Joint Space Outcomes with High-resolution Peripheral Quantitative Computed Tomography.

Authors :: Manske SL
Brunet SC
Finzel S
Stok KS
Conaghan PG
Boyd SK
Barnabe C
Source :: The Journal of rheumatology [J Rheumatol] 2019 Oct; Vol. 46 (10), pp. 1369-1373. Date of Electronic Publication: 2019 Jan 15.
Publication Year :: 2019
Abstract: Objective: We assessed construct validity of high-resolution peripheral quantitative computed tomography (HR-pQCT) joint space outcomes by comparison with radiographs in patients with rheumatoid arthritis.<br />Methods: In 43 patients, quantitative, volumetric, HR-pQCT measurements were compared with ordinal Sharp/van der Heijde scoring (SvdH) in the 2nd and 3rd metacarpophalangeal joints.<br />Results: Generalized estimating equations showed that joint space minimum, SD, and asymmetry by HR-pQCT were associated with SvdH scores (p < 0.05). There was a considerable range in HR-pQCT measurements at SvdH equal to 0.<br />Conclusion: HR-pQCT demonstrated construct validity outcomes and provides improved 3-D visualization of joint space.

Subjects :: Adult
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Imaging, Three-Dimensional methods
Male
Middle Aged
Reproducibility of Results
Research Design
Severity of Illness Index
Young Adult
Arthritis, Rheumatoid diagnostic imaging
Metacarpophalangeal Joint diagnostic imaging
Outcome Assessment, Health Care methods
Radiography methods
Tomography, X-Ray Computed methods

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