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Pituitary macroadenoma: Accuracy of apparent diffusion coefficient magnetic resonance imaging in grading tumor aggressiveness.
- Source :
-
The neuroradiology journal [Neuroradiol J] 2019 Apr; Vol. 32 (2), pp. 86-91. Date of Electronic Publication: 2019 Jan 16. - Publication Year :
- 2019
-
Abstract
- Purpose: The purpose of this study is to evaluate the accuracy of apparent diffusion coefficient magnetic resonance imaging in grading tumor aggressiveness using histogram apparent diffusion coefficient values.<br />Materials and Methods: Eighteen patients with surgically proved pituitary macroadenomas were included in this study. Diffusion-weighted imaging with single-shot echo-planar sequence at 3-T with a 32-channel head coil was performed with b values of 0 and 1000 s/mm <superscript>2</superscript> . Calculated apparent diffusion coefficient maps were generated, and a 3-D volume of interest was placed on the tumor while superimposing contrast-enhanced magnetic resonance images. All apparent diffusion coefficient values within the volume of interest were used to compute the average apparent diffusion coefficient of the tumor. The apparent diffusion coefficient values were binned to construct the apparent diffusion coefficient histogram. Using the histogram, the mean, percentiles, skewness, and kurtosis of the apparent diffusion coefficient of the entire tumor were computed. Apparent diffusion coefficient histogram parameters were compared with the MIB-1 index, invasiveness, and recurrence for grading tumor aggressiveness of pituitary adenomas.<br />Results: The skewness of the apparent diffusion coefficient histogram only showed significant differences among MIB-1 indices ( p = 0.030). All apparent diffusion coefficient histogram parameters showed no significant differences between negative and positive invasion. The skewness and kurtosis of the apparent diffusion coefficient histogram showed significant differences between positive and negative recurrence (skewness p = 0.011, kurtosis p = 0.011). Receiver-operating characteristics analysis between positive and negative recurrence showed that both skewness and kurtosis of the apparent diffusion coefficient achieved area under the curve at 0.967.<br />Conclusion: Skewness and kurtosis of the apparent diffusion coefficient histogram were the predictive parameters for assessing tumor proliferative potential and recurrence of pituitary adenomas.
- Subjects :
- Adult
Aged
Contrast Media
Echo-Planar Imaging
Female
Humans
Image Interpretation, Computer-Assisted
Male
Middle Aged
Neoplasm Grading
Retrospective Studies
Sensitivity and Specificity
Adenoma diagnostic imaging
Adenoma pathology
Diffusion Magnetic Resonance Imaging
Pituitary Neoplasms diagnostic imaging
Pituitary Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2385-1996
- Volume :
- 32
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The neuroradiology journal
- Publication Type :
- Academic Journal
- Accession number :
- 30648472
- Full Text :
- https://doi.org/10.1177/1971400919825696