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From Target Identification to Drug Development in Space: Using the Microgravity Assist.
- Source :
-
Current drug discovery technologies [Curr Drug Discov Technol] 2020; Vol. 17 (1), pp. 45-56. - Publication Year :
- 2020
-
Abstract
- The unique nature of microgravity encountered in space provides an opportunity for drug discovery and development that cannot be replicated on Earth. From the production of superior protein crystals to the identification and validation of new drug targets to microarray analyses of transcripts attenuated by microgravity, there are numerous examples which demonstrate the benefit of exploiting the space environment. Moreover, studies conducted on Space Shuttle missions, the International Space Station and other craft have had a direct benefit for drug development programmes such as those directed against reducing bone and muscle loss or increasing bone formation. This review will highlight advances made in both drug discovery and development and offer some future insight into how drug discovery and associated technologies may be further advanced using the microgravity assist.<br /> (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
- Subjects :
- Animals
Bone Density drug effects
Bone Density physiology
Crystallography, X-Ray methods
Disease Models, Animal
Drug Development trends
Drug Discovery trends
Gene Expression Profiling methods
Humans
Mice
Muscular Atrophy drug therapy
Muscular Atrophy physiopathology
Oligonucleotide Array Sequence Analysis methods
Osteoporosis drug therapy
Osteoporosis physiopathology
Drug Development methods
Drug Discovery methods
Space Flight
Weightlessness
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6220
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current drug discovery technologies
- Publication Type :
- Academic Journal
- Accession number :
- 30648510
- Full Text :
- https://doi.org/10.2174/1570163816666190112150014