Back to Search
Start Over
Acyclovir Unresponsive Herpes Simplex Encephalitis in a child successfully treated with the addition of Foscarnet: Case report.
- Source :
-
Archivos argentinos de pediatria [Arch Argent Pediatr] 2019 Feb 01; Vol. 117 (1), pp. e47-e51. - Publication Year :
- 2019
-
Abstract
- Herpes simplex encephalitis (HSE) is the most common cause of sporadic focal encephalitis worldwide. Acyclovir is the treatment of choice of HSE since the 1980s. After the widespread use of acyclovir, HSE related mortality rate had reduced but resistant strains emerged. Acyclovir resistant HSV incidence was reported as about 0.5 % and 3.5 %-10 % in immunocompetent and immunocompromised patients, respectively. Herein, a 12-year-old immunocompetent patient with HSV-1 encephalitis who was successfully treated with combined acyclovir and foscarnet therapy is described. In the case of deteriorating clinical condition under acyclovir treatment even if the absence of demonstration of increased CSF HSV viral load, the possibility of acyclovir resistant HSE and the addition of foscarnet to the acyclovir treatment might be considered.<br /> (Sociedad Argentina de Pediatría.)
- Subjects :
- Acyclovir pharmacology
Antiviral Agents pharmacology
Child
Drug Combinations
Drug Resistance, Viral
Humans
Male
Remission Induction
Simplexvirus drug effects
Treatment Failure
Acyclovir therapeutic use
Antiviral Agents therapeutic use
Encephalitis, Herpes Simplex drug therapy
Foscarnet administration & dosage
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1668-3501
- Volume :
- 117
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archivos argentinos de pediatria
- Publication Type :
- Academic Journal
- Accession number :
- 30652455
- Full Text :
- https://doi.org/10.5546/aap.2019.eng.e47