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Incidence and Ocular Features of Pediatric Myasthenias.
- Source :
-
American journal of ophthalmology [Am J Ophthalmol] 2019 Apr; Vol. 200, pp. 242-249. Date of Electronic Publication: 2019 Jan 14. - Publication Year :
- 2019
-
Abstract
- Purpose: To report the incidence, demographics, and ocular findings of children with myasthenia.<br />Design: Retrospective cohort study.<br />Methods: The medical records of all children (<19 years) examined at Mayo Clinic with any form of myasthenia from January 1 1966, through December 31, 2015, were retrospectively reviewed.<br />Results: A total of 364 children were evaluated during the study period, of which 6 children were residents of the Olmsted County at the time of their diagnosis, yielding an annual age- and sex-adjusted incidence of 0.35 per 100 000 <19 years, or 1 in 285 714 <19 years. The incidence of juvenile myasthenia gravis (JMG) and congenital myasthenic syndrome (CMS) was 0.12 and 0.23 per 100 000, respectively. Of the 364 study children, 217 (59.6%) had JMG, 141 (38.7%) had CMS, and 6 (1.7%) had Lambert-Eaton syndrome, diagnosed at a median age of 13.5, 5.1, and 12.6 years, respectively. A majority of the JMG and CMS patients had ocular involvement (90.3% and 85.1%, respectively), including ptosis and ocular movement deficits. Among children with at least 1 year of follow-up (JMG; median, 7.1 years, CMS; median, 7.0 years), improvement was seen in 88.8% of JMG patients (complete remission in 31.3%) and in 58.3% of CMS patients.<br />Conclusion: Although relatively rare, myasthenia gravis in children has 2 predominant forms, CMS and JMG, both of which commonly have ocular involvement. Improvement is more likely in children with the juvenile form.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Age of Onset
Autoantibodies blood
Child
Child, Preschool
Disease Progression
Electromyography
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Minnesota epidemiology
Oculomotor Muscles pathology
Receptors, Cholinergic immunology
Retrospective Studies
Myasthenia Gravis diagnosis
Myasthenia Gravis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1891
- Volume :
- 200
- Database :
- MEDLINE
- Journal :
- American journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 30653958
- Full Text :
- https://doi.org/10.1016/j.ajo.2019.01.004