Back to Search
Start Over
Low Transthyretin Levels Predict Poor Prognosis in Cancer Patients in Palliative Care Settings.
- Source :
-
Nutrition and cancer [Nutr Cancer] 2018 Nov-Dec; Vol. 70 (8), pp. 1283-1289. Date of Electronic Publication: 2019 Jan 20. - Publication Year :
- 2018
-
Abstract
- Objectives: Although transthyretin (TTR) is a nutritional indicator and is influenced by systemic inflammation, it may be a good prognostic indicator for cancer patients in palliative care settings. This study investigates the correlation between low TTR levels and survival among cancer patients in palliative care settings.<br />Methods: This was a sub-analysis of a prospective, multicenter cohort study. Patients who had advanced-stage cancer and who were newly referred to palliative care services were eligible to participate; however, those receiving anti-tumor therapy were excluded. Survival analyses were performed to clarify predictors of poor prognosis.<br />Results: A total of 144 patients were enrolled (45.1% female; median age, 72 years). Cox regression analysis revealed that low TTR levels (<10.9 mg/l) (hazard ratio 1.74, P = 0.025), poor muscle power (1.71, P = 0.045), and fatigue (1.89, P = 0.024) were predictors of poor prognosis. Median survival in patients with low TTR levels (<10.9 mg/l) was 26 days, which was significantly shorter than those with high TTR levels (≥10.9 mg/l) (50 days; P < 0.001).<br />Conclusion: Low TTR levels may be indicators for poor prognosis among cancer patients in palliative care settings.
Details
- Language :
- English
- ISSN :
- 1532-7914
- Volume :
- 70
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30663397
- Full Text :
- https://doi.org/10.1080/01635581.2018.1557213