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Lymph node metastasis in Chinese patients with clinical T1 non-small cell lung cancer: A multicenter real-world observational study.
- Source :
-
Thoracic cancer [Thorac Cancer] 2019 Mar; Vol. 10 (3), pp. 533-542. Date of Electronic Publication: 2019 Jan 21. - Publication Year :
- 2019
-
Abstract
- Background: Approximately 8.3-15.9% of patients with clinical stage I non-small cell lung cancer are subsequently shown to have lymph node metastasis. However, the clinical characteristics of patients with lymph node metastasis in China are not fully understood.<br />Methods: This is a multicenter retrospective analysis of pathological T1 non-small cell lung cancer patients who underwent surgical resection from 2 January 2014 to 27 December 2017. Clinical and pathological information was collected with the assistance of the Large-scale Data Analysis Center of Cancer Precision Medicine-LinkDoc database. The clinical and pathological factors associated with lymph node metastasis were analyzed by univariate and multivariate logistic regression.<br />Results: A total of 10 885 participants (51.6% women; 15.3% squamous cell carcinoma) were included in the analysis. The median age was 60.0 years (range 12.9-86.6 years). A total of 1159 patients (10.6%) had metastases in mediastinal nodes (N2), and 640 patients (5.9%) had metastasis in pulmonary lymph nodes (N1). Most patients had T1b lung cancer (4766, 43.8%). Of the patients, 3260 (29.9%) were current or former smokers. The univariate and multivariate analyses showed that younger age, squamous cell carcinoma, poor differentiation, larger tumor size, carcinoembryonic antigen level ≥5 ng/mL, and vascular invasion (+) were significantly associated with higher percentages of lymph node metastases (P < 0.001 for all).<br />Conclusion: This real-world study showed the significant association of lymph node metastasis with age, tumor size, histology and differentiation, carcinoembryonic antigen levels, and status of vascular invasion. Female patients with T1a adenocarcinoma in the right upper lobe barely had lymph node metastasis.<br /> (© 2019 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Adenocarcinoma pathology
Adenocarcinoma surgery
Adult
Biomarkers, Tumor genetics
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung surgery
China epidemiology
Female
Humans
Logistic Models
Lymph Node Excision
Lymph Nodes pathology
Male
Mediastinum pathology
Middle Aged
Neoplasm Staging
Adenocarcinoma epidemiology
Carcinoma, Non-Small-Cell Lung epidemiology
Lymphatic Metastasis
Prognosis
Subjects
Details
- Language :
- English
- ISSN :
- 1759-7714
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Thoracic cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30666800
- Full Text :
- https://doi.org/10.1111/1759-7714.12970