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A defined commensal consortium elicits CD8 T cells and anti-cancer immunity.
- Source :
-
Nature [Nature] 2019 Jan; Vol. 565 (7741), pp. 600-605. Date of Electronic Publication: 2019 Jan 23. - Publication Year :
- 2019
-
Abstract
- There is a growing appreciation for the importance of the gut microbiota as a therapeutic target in various diseases. However, there are only a handful of known commensal strains that can potentially be used to manipulate host physiological functions. Here we isolate a consortium of 11 bacterial strains from healthy human donor faeces that is capable of robustly inducing interferon-γ-producing CD8 T cells in the intestine. These 11 strains act together to mediate the induction without causing inflammation in a manner that is dependent on CD103 <superscript>+</superscript> dendritic cells and major histocompatibility (MHC) class Ia molecules. Colonization of mice with the 11-strain mixture enhances both host resistance against Listeria monocytogenes infection and the therapeutic efficacy of immune checkpoint inhibitors in syngeneic tumour models. The 11 strains primarily represent rare, low-abundance components of the human microbiome, and thus have great potential as broadly effective biotherapeutics.
- Subjects :
- Adenocarcinoma pathology
Animals
Antigens, CD metabolism
Bacteria immunology
Bacteria isolation & purification
CD8-Positive T-Lymphocytes cytology
Cell Line, Tumor
Dendritic Cells immunology
Feces microbiology
Female
Healthy Volunteers
Histocompatibility Antigens Class I immunology
Humans
Integrin alpha Chains metabolism
Interferon-gamma biosynthesis
Interferon-gamma immunology
Listeria monocytogenes immunology
Listeriosis immunology
Listeriosis microbiology
Male
Mice
Programmed Cell Death 1 Receptor antagonists & inhibitors
Programmed Cell Death 1 Receptor immunology
Xenograft Model Antitumor Assays
Adenocarcinoma immunology
Adenocarcinoma therapy
Bacteria classification
CD8-Positive T-Lymphocytes immunology
Gastrointestinal Microbiome immunology
Listeriosis prevention & control
Symbiosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 565
- Issue :
- 7741
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 30675064
- Full Text :
- https://doi.org/10.1038/s41586-019-0878-z