Feasibility of carbon-ion radiotherapy for oral non-squamous cell carcinomas.

Authors :: Ikawa H
Koto M
Hayashi K
Tonogi M
Takagi R
Nomura T
Tsuji H
Kamada T
Source :: Head & neck [Head Neck] 2019 Jun; Vol. 41 (6), pp. 1795-1803. Date of Electronic Publication: 2019 Jan 24.
Publication Year :: 2019
Abstract: Background: This study evaluated carbon-ion radiotherapy (C-ion RT) for oral non-squamous cell carcinomas (non-SCC).<br />Methods: We retrospectively obtained data from 74 patients who underwent C-ion RT for oral malignancies between April 1997 and March 2016. The C-ion RT was administered in 16 fractions at a total dose of 57.6 or 64.0 Gy (relative biological effectiveness).<br />Results: Forty-three patients had salivary gland carcinomas, 29 patients had mucosal melanoma, and 2 patients had other types of pathologies. The tumors were classified as T1-T3 (24 cases), T4a (21 cases), or T4b (29 cases). The median follow-up was 49 months. The 5-year rates were 78.8% for local control, 36.2% for progression-free survival, and 58.3% for overall survival. Although 10 patients developed grade 3 osteoradionecrosis after C-ion RT, all patients maintained their mastication and deglutition functions after sequestrectomy and prosthesis placement.<br />Conclusion: C-ion RT was effective for oral non-SCC and had acceptable toxicities.<br /> (© 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc.)