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Comparison of subjective and objective assessment of glucocorticoid response in nasal polyps: a preliminary study.
- Source :
-
Acta oto-laryngologica [Acta Otolaryngol] 2019 Jan; Vol. 139 (1), pp. 57-63. Date of Electronic Publication: 2019 Jan 24. - Publication Year :
- 2019
-
Abstract
- Background: Glucocorticoids (GC) therapeutic response in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) varies markedly.<br />Aims/objectives: To compare the utility between subjective and objective assessment of GC sensitivity in reflecting the impact of GC on systemic and local eosinophilia in CRSwNP patients.<br />Material and Methods: Twenty-six patients with CRSwNP were enrolled. All patients were given 30 mg of prednisone once daily for 7 days and subsequently classified into subjectively GC-sensitive and -insensitive subgroup or objectively GC-sensitive and -insensitive subgroup. The numbers of eosinophils and neutrophils in blood and polyp tissues were compared between GC-sensitive and GC-insensitive subgroup.<br />Results: 17/26 (65.4%) patients were subjectively and 8/26 (30.8%) patients objectively sensitive to GC treatment. The absolute number and percentage of eosinophils in blood were decreased both in GC-sensitive and -insensitive subjects after GC treatment. In addition, a significant reduction in tissue eosinophil percentage was only observed in objectively GC-sensitive subjects after GC treatment. Furthermore, the change of tissue eosinophil percentage in objectively GC-sensitive subjects was significantly higher than that in objectively GC-insensitive subjects.<br />Conclusions and Significance: Objective assessment may better reflect oral GC response in tissue eosinophilic inflammation than subjective assessment in patients with CRSwNP.
Details
- Language :
- English
- ISSN :
- 1651-2251
- Volume :
- 139
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta oto-laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 30676835
- Full Text :
- https://doi.org/10.1080/00016489.2018.1541507