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[The CD45-positive thrombocytes and neutrophils/lymphocytes level ratio in evaluation of risk of development of re-stenosis шт patients with chronic ischemic heart disease and diabetes mellitus type II.]
- Source :
-
Klinicheskaia laboratornaia diagnostika [Klin Lab Diagn] 2018; Vol. 63 (4), pp. 233-238. - Publication Year :
- 2018
-
Abstract
- The purpose of study is to investigate significance of detection of number of CD45-positive thrombocytes and ratio neutrophils/lymphocytes in evaluation of risk of development of re-stenosis after implantation of drug-eluting stents in patients with chronic ischemic heart disease and diabetes mellitus type II. The examination was applied to 126 patients with chronic forms of ischemic heart disease who passed through repeat coronary angiography during first year after implantation of drug-eluting stents. The patients were separated on two groups depending on availability of diabetes mellitus type II. In both groups, the patients passed through comparing of angiography and clinical characteristics. Also, a logistic model was developed prognosticating development of re-stenosis. The re-stenosis developed more often in patients with diabetes mellitus type II (54.5%) than in patients without diabetes mellitus type II (32.4%; p=0.01). The comparative analysis of more than 35 characteristics permitted to establish risk factors of development of re-stenosis with the highest prognosticating capacity among patients with diabetes mellitus type II. These risk factors were CD45-positive thrombocytes and ratio neutrophils/lymphocytes. To prognosticate development of re-stenosis a logistic regression model was developed comprising number of circulating CD45-positive thrombocytes, ratio neutrophils/lymphocytes and availability of diabetes mellitus type II. The model demonstrated high prognosticating value as regards development of re-stenosis: OR = 15.1 (95% CI 4.81-31, p < 0.001). The square under ROC-curve: AUC = 0.83 (95% CI 0,72-0,92; р < 0,001). The increasing of number of circulating CD45-positive thrombocytes and ratio neutrophils/lymphocytes can be considered as a valuable risk factors of development of re-stenosis in case of diabetes mellitus type II.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Constriction, Pathologic
Coronary Angiography
Diabetes Mellitus, Type 2 blood
Drug-Eluting Stents
Humans
Leukocyte Common Antigens
Myocardial Ischemia blood
Risk Factors
Treatment Outcome
Blood Platelets cytology
Coronary Restenosis blood
Diabetes Mellitus, Type 2 complications
Lymphocytes cytology
Myocardial Ischemia complications
Neutrophils cytology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0869-2084
- Volume :
- 63
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Klinicheskaia laboratornaia diagnostika
- Publication Type :
- Academic Journal
- Accession number :
- 30677279
- Full Text :
- https://doi.org/10.18821/0869-2084-2018-63-4-233-238