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Sodium lactate infusions after treatment with tricyclic antidepressants: behavioral and physiological findings.

Authors :
Yeragani VK
Pohl R
Balon R
Rainey JM
Berchou R
Ortiz A
Source :
Biological psychiatry [Biol Psychiatry] 1988 Nov; Vol. 24 (7), pp. 767-74.
Publication Year :
1988

Abstract

Fourteen patients with panic disorder were infused with sodium lactate both before and after treatment with tricyclic antidepressants. All patients had panic attacks before treatment, and only five after treatment. There was a significant decrease in measures of anxiety prior to and during infusions after treatment. The patients were able to tolerate more lactate during reinfusions. The comparison of reinfusion panickers and nonpanickers revealed that the reinfusion panickers had higher levels of anxiety, as measured by psychological symptoms on the Panic Description Scale, during both their pretreatment and posttreatment infusions. Tricyclic antidepressants appear to increase the threshold for lactate-induced panic attacks.

Details

Language :
English
ISSN :
0006-3223
Volume :
24
Issue :
7
Database :
MEDLINE
Journal :
Biological psychiatry
Publication Type :
Academic Journal
Accession number :
3067755
Full Text :
https://doi.org/10.1016/0006-3223(88)90252-1