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Sodium lactate infusions after treatment with tricyclic antidepressants: behavioral and physiological findings.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1988 Nov; Vol. 24 (7), pp. 767-74. - Publication Year :
- 1988
-
Abstract
- Fourteen patients with panic disorder were infused with sodium lactate both before and after treatment with tricyclic antidepressants. All patients had panic attacks before treatment, and only five after treatment. There was a significant decrease in measures of anxiety prior to and during infusions after treatment. The patients were able to tolerate more lactate during reinfusions. The comparison of reinfusion panickers and nonpanickers revealed that the reinfusion panickers had higher levels of anxiety, as measured by psychological symptoms on the Panic Description Scale, during both their pretreatment and posttreatment infusions. Tricyclic antidepressants appear to increase the threshold for lactate-induced panic attacks.
- Subjects :
- Clinical Trials as Topic
Desipramine therapeutic use
Double-Blind Method
Doxepin therapeutic use
Humans
Imipramine therapeutic use
Isoproterenol
Lactic Acid
Nortriptyline therapeutic use
Psychological Tests
Antidepressive Agents, Tricyclic therapeutic use
Arousal drug effects
Fear drug effects
Lactates
Panic drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 24
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 3067755
- Full Text :
- https://doi.org/10.1016/0006-3223(88)90252-1