In vitro evaluation of antifungal combination against Cryptococcus neoformans.

Authors :: Rossato L
Loreto ES
Venturini TP
Azevedo MI
Al-Hatmi AMS
Santurio JM
Alves SH
Source :: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2019 Jun; Vol. 94 (2), pp. 155-156. Date of Electronic Publication: 2018 Dec 08.
Publication Year :: 2019
Abstract: This study evaluated combinations of amphotericin B with anidulafungin, caspofungin, and micafungin against 30 clinical isolates of Cryptococcus neoformans following the CLSI M27-A3 and the checkerboard microdilution method. The combination amphotericin B + micafungin showed 60% of synergistic effect against C. neoformans, while most of the other interactions were indifferent.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)