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Myricetin nanoliposomes induced SIRT3-mediated glycolytic metabolism leading to glioblastoma cell death.
- Source :
-
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2018; Vol. 46 (sup3), pp. S180-S191. Date of Electronic Publication: 2019 Jan 28. - Publication Year :
- 2018
-
Abstract
- As the most aggressive and malignant glioma, glioblastoma multiforme (GBM) abnormally expresses genes that mediate glycolytic metabolism and tumour cell growth. In this study, we investigated myricetin incorporated nanoliposomes and ascertained their prospect in effectively treating cancer via the employment of the GBM cell line DBTRG-05MG. Notably, the myricetin nanoliposomes (MYR-NLs) displayed potent inhibition of proliferation and significantly regulated the levels of proteins related to both glycolytic metabolism and cell survival. Most importantly, SIRT3 and phosphorylated p53 were also down-regulated by MYR-NLs, indicating that the MYR-NLs inhibited GBM cell growth through the SIRT3/p53-mediated PI3K/Akt-ERK and mitochondrial pathways. Our findings thus provide rational evidence that liposomal myricetin targeted at alternative cell death pathways may be a useful adjuvant therapy in glioblastoma treatment.
- Subjects :
- Cell Line, Tumor
Humans
Liposomes
Apoptosis drug effects
Brain Neoplasms drug therapy
Brain Neoplasms metabolism
Brain Neoplasms pathology
Flavonoids chemistry
Flavonoids pharmacology
Glioblastoma drug therapy
Glioblastoma metabolism
Glioblastoma pathology
Glycolysis drug effects
Nanoparticles chemistry
Nanoparticles therapeutic use
Neoplasm Proteins biosynthesis
Sirtuin 3 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 2169-141X
- Volume :
- 46
- Issue :
- sup3
- Database :
- MEDLINE
- Journal :
- Artificial cells, nanomedicine, and biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 30691320
- Full Text :
- https://doi.org/10.1080/21691401.2018.1489825