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Essential roles of C-type lectin Mincle in induction of neuropathic pain in mice.
- Source :
-
Scientific reports [Sci Rep] 2019 Jan 29; Vol. 9 (1), pp. 872. Date of Electronic Publication: 2019 Jan 29. - Publication Year :
- 2019
-
Abstract
- Increasing evidence indicates that pattern recognition receptors (PRRs) are involved in neuropathic pain after peripheral nerve injury (PNI). While a significant number of studies support an association between neuropathic pain and the innate immune response mediated through Toll-like receptors, a family of PRRs, the roles of other types of PRRs are largely unknown. In this study, we have focused on the macrophage-inducible C-type lectin (Mincle), a PRR allocated to the C-type lectin receptor family. Here, we show that Mincle is involved in neuropathic pain after PNI. Mincle-deficient mice showed impaired PNI-induced mechanical allodynia. After PNI, expression of Mincle mRNA was rapidly increased in the injured spinal nerve. Most Mincle-expressing cells were identified as infiltrating leucocytes, although the migration of leucocytes was also observed in Mincle-deficient mice. Furthermore, Mincle-deficiency affected the induction of genes, which are reported to contribute to neuropathic pain after PNI in the dorsal root ganglia and spinal dorsal horn. These results suggest that Mincle is involved in triggering sequential processes that lead to the pathogenesis of neuropathic pain.
- Subjects :
- Animals
Disease Models, Animal
Ganglia, Spinal metabolism
Hyperalgesia metabolism
Immunity, Innate
Lectins, C-Type physiology
Macrophages metabolism
Male
Membrane Proteins physiology
Mice
Mice, Inbred C57BL
Neuralgia physiopathology
Peripheral Nerve Injuries metabolism
Receptors, Pattern Recognition metabolism
Spinal Cord Dorsal Horn metabolism
Spinal Nerves pathology
Toll-Like Receptors metabolism
Lectins, C-Type metabolism
Membrane Proteins metabolism
Neuralgia metabolism
Peripheral Nerve Injuries physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 30696945
- Full Text :
- https://doi.org/10.1038/s41598-018-37318-8