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Differences and similarities between IgG4-related disease with and without dacryoadenitis and sialoadenitis: clinical manifestations and treatment efficacy.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2019 Feb 01; Vol. 21 (1), pp. 44. Date of Electronic Publication: 2019 Feb 01. - Publication Year :
- 2019
-
Abstract
- Background: This study aimed to compare the differences and similarities in the clinical manifestations and treatment efficacy of IgG4-related disease (IgG4-RD) in patients with and without dacryoadenitis and sialoadenitis (DS).<br />Methods: A total of 121 untreated IgG4-RD patients in Peking Union Medical College Hospital were enrolled in this study. The patients were divided into three groups: DS-predominant (group A), non-DS (group B), and DS with other internal organs affected (group C). The patients were followed up for at least 15 months. Baseline and follow-up data were collected. The disease activity was evaluated according to the IgG4-RD responder index.<br />Results: The mean ± SD age at disease onset was 53.2 ± 14.1 years, and 71.9% of the patients were male. The prevalence of allergies was higher in groups A (21, 61.8%) and C (32, 69.6%) than group B (14, 34.1%). More patients with DS (17, 50.0%, and 17, 37.0%) had sinonasal lesions than those without DS (5, 12.2%). Moreover, an increased number of eosinophils were more common in patients with DS than in those without, as were increased serum IgG, IgG4, and IgE levels. More patients in group B and group C (28, 68.3%, and 31, 67.4%) received a combination therapy of corticosteroid and immunosuppressant. During the 15-month follow-up, 28 (23.1%) patients had disease relapse.<br />Conclusion: Results demonstrated that IgG4-RD patients with DS had distinctive clinical features compared with non-DS. Allergy and sinonasal involvement were more common in patients with DS. Patients with DS showed higher serum IgG4 levels than those without DS.
- Subjects :
- Adult
Aged
Dacryocystitis blood
Dacryocystitis complications
Drug Therapy, Combination
Eosinophils metabolism
Female
Humans
Immunoglobulin E blood
Immunoglobulin G blood
Immunoglobulin G4-Related Disease blood
Immunoglobulin G4-Related Disease complications
Male
Middle Aged
Sialadenitis blood
Sialadenitis complications
Treatment Outcome
Dacryocystitis drug therapy
Glucocorticoids therapeutic use
Immunoglobulin G4-Related Disease drug therapy
Immunosuppressive Agents therapeutic use
Sialadenitis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 30709411
- Full Text :
- https://doi.org/10.1186/s13075-019-1828-8