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Slc20a2, Encoding the Phosphate Transporter PiT2, Is an Important Genetic Determinant of Bone Quality and Strength.
- Source :
-
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2019 Jun; Vol. 34 (6), pp. 1101-1114. Date of Electronic Publication: 2019 Mar 19. - Publication Year :
- 2019
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Abstract
- Osteoporosis is characterized by low bone mineral density (BMD) and fragility fracture and affects over 200 million people worldwide. Bone quality describes the material properties that contribute to strength independently of BMD, and its quantitative analysis is a major priority in osteoporosis research. Tissue mineralization is a fundamental process requiring calcium and phosphate transporters. Here we identify impaired bone quality and strength in Slc20a2 <superscript>-/-</superscript> mice lacking the phosphate transporter SLC20A2. Juveniles had abnormal endochondral and intramembranous ossification, decreased mineral accrual, and short stature. Adults exhibited only small reductions in bone mass and mineralization but a profound impairment of bone strength. Bone quality was severely impaired in Slc20a2 <superscript>-/-</superscript> mice: yield load (-2.3 SD), maximum load (-1.7 SD), and stiffness (-2.7 SD) were all below values predicted from their bone mineral content as determined in a cohort of 320 wild-type controls. These studies identify Slc20a2 as a physiological regulator of tissue mineralization and highlight its critical role in the determination of bone quality and strength. © 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.<br /> (© 2019 The Authors. Journal of Bone and Mineral Research Published by Wiley Periodicals Inc.)
- Subjects :
- Animals
Animals, Newborn
Bone Development
Bone Resorption physiopathology
Bone and Bones diagnostic imaging
Calcification, Physiologic
Calcinosis diagnostic imaging
Calcinosis genetics
Cells, Cultured
Chondrocytes metabolism
Humans
Incisor ultrastructure
Mice, Inbred C57BL
Mice, Knockout
Osteoblasts metabolism
Phenotype
Skull diagnostic imaging
Sodium-Phosphate Cotransporter Proteins, Type III deficiency
Tooth growth & development
X-Ray Microtomography
Bone and Bones physiology
Sodium-Phosphate Cotransporter Proteins, Type III genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1523-4681
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
- Publication Type :
- Academic Journal
- Accession number :
- 30721528
- Full Text :
- https://doi.org/10.1002/jbmr.3691