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Tumor stromal desmoplasia and inflammatory response uniquely predict survival with and without stratification for HPV tumor infection in OPSCC patients.

Authors :
Haave H
Gulati S
Brekke J
Lybak S
Vintermyr OK
Aarstad HJ
Source :
Acta oto-laryngologica [Acta Otolaryngol] 2018 Nov; Vol. 138 (11), pp. 1035-1042. Date of Electronic Publication: 2019 Feb 08.
Publication Year :
2018

Abstract

Background: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide.<br />Aims/objectives: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients.<br />Material and Methods: Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS.<br />Results: High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients.<br />Conclusion: Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value.<br />Significance: We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.

Details

Language :
English
ISSN :
1651-2251
Volume :
138
Issue :
11
Database :
MEDLINE
Journal :
Acta oto-laryngologica
Publication Type :
Academic Journal
Accession number :
30734620
Full Text :
https://doi.org/10.1080/00016489.2018.1497809