Back to Search
Start Over
Actigraphy as an assessment of performance status in patients with advanced lung cancer.
- Source :
-
Palliative & supportive care [Palliat Support Care] 2019 Oct; Vol. 17 (5), pp. 574-578. - Publication Year :
- 2019
-
Abstract
- Objective: Wearable devices such as a wrist actigraph may have a potential to objectively estimate patients' functioning and may supplement performance status (PS). This proof-of-concept study aimed to evaluate whether actigraphy data are significantly associated with patients' functioning and are predictive of their survival in patients with metastatic non-small cell lung cancer.<br />Method: We collected actigraphy data for a three-day period in ambulatory patients with stage IV non-small cell lung cancer. We computed correlations between actigraphy data (specifically, proportion of time spent immobile while awake) and clinician-rated PS, subjective report of physical activities, quality of life (the Functional Assessment of Cancer Therapy - Trial Outcome Index), and survival.<br />Result: Actigraphy data (the proportion of time awake spent immobile) were significantly correlated with Functional Assessment of Cancer Therapy - Trial Outcome Index (r = -0.53, p < 0.001) and with the Eastern Cooperative Oncology Group PS (ECOG PS) (r = 0.37, p < 0.001). The proportion of time awake spent immobile was significantly associated with worse survival. For each 10% increase in this measure, the hazard ratio (HR) was 1.48 (95% confidence interval [CI95%] = 1.06, 2.06) for overall mortality, and odds ratio was 2.99 (CI95% = 1.27, 7.05) for six-month mortality. ECOG PS was also associated with worse survival (HR = 2.80, CI95% = 1.34, 5.86). Among patients with ECOG PS 0-1, the percentage of time awake spent immobile was significantly associated with worse survival, HR = 1.93 (CI95% = 1.10, 3.42), whereas ECOG PS did not predict survival.<br />Significance of Results: Actigraphy may have potential to predict important clinical outcomes, such as quality of life and survival, and may serve to supplement PS. Further validation study is warranted.
- Subjects :
- Actigraphy instrumentation
Actigraphy statistics & numerical data
Aged
Carcinoma, Non-Small-Cell Lung classification
Female
Humans
Male
Middle Aged
Odds Ratio
Prospective Studies
Quality of Life psychology
Surveys and Questionnaires
Actigraphy methods
Carcinoma, Non-Small-Cell Lung physiopathology
Physical Fitness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-9523
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Palliative & supportive care
- Publication Type :
- Academic Journal
- Accession number :
- 30739635
- Full Text :
- https://doi.org/10.1017/S1478951518001074