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Pre-Operative vs. Peri-Operative Nutrition Supplementation in Hepatic Resection for Cancer: A Systematic Review.
- Source :
-
Nutrition and cancer [Nutr Cancer] 2019; Vol. 71 (2), pp. 179-198. Date of Electronic Publication: 2019 Feb 09. - Publication Year :
- 2019
-
Abstract
- Despite improvements in safety of hepatic resection post-operative complications occur in up to a half of patients. A systematic review was undertaken to compare the effect of pre-operative and peri-operative nutritional supplementation on post-operative outcomes in patients undergoing hepatic resection for malignancy. Included studies were identified through a search of PubMed (1966 to November 2016), Embase (1947 to November 2016) and the Cochrane Library (1993 to November 2016). Eleven studies involving a total of 725 patients were included in this systematic review. BCAA supplementation in the pre-operative and peri-operative period was reported to reduce the overall complication rate by 26.9% (Pā=ā0.01) in one cohort study while pre-operative immunonutrition was shown to reduce post-operative ascites by 25.4% (Pā=0.012) in another cohort study without affecting the overall complication rate. Four further studies on enteral supplementation failed to show a benefit with regards to post-operative complications. Post-operative mortality was unaffected by pre-operative and peri-operative BCAA. Both pre-operative and peri-operative nutritional supplementation have shown promising results regarding the post-operative course of patients undergoing hepatic resection for malignancy. No randomized controlled study exists directly comparing pre-operative and peri-operative nutrition and this needs to be focused on in future research.
- Subjects :
- Cohort Studies
Hepatectomy methods
Humans
Perioperative Care methods
Postoperative Complications etiology
Postoperative Complications mortality
Preoperative Care methods
Randomized Controlled Trials as Topic
Dietary Supplements
Liver Neoplasms diet therapy
Liver Neoplasms mortality
Liver Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1532-7914
- Volume :
- 71
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nutrition and cancer
- Publication Type :
- Academic Journal
- Accession number :
- 30741015
- Full Text :
- https://doi.org/10.1080/01635581.2018.1560479