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Cell volume regulation in renal cortical cells.

Authors :
Völkl H
Paulmichl M
Lang F
Source :
Renal physiology and biochemistry [Ren Physiol Biochem] 1988 May-Oct; Vol. 11 (3-5), pp. 158-73.
Publication Year :
1988

Abstract

Both proximal renal tubule cells and cultured Madin-Darby canine kidney (MDCK) cells are capable of regulating their volume in hypotonic media. Regulatory cell volume decrease in proximal straight tubules is impaired by barium, amiloride and acetazolamide and depends on the presence of bicarbonate and of sodium, whereas it is unaffected by complete removal of extracellular chloride. The observations may point to parallel loss of potassium through potassium channels as well as of bicarbonate and sodium via a bicarbonate-sodium cotransport. Alternatively, potassium/hydrogen ion exchange or potassium bicarbonate cotransport could be involved. In MDCK cells, exposure to hypotonic media apparently leads to the activation of an anion channel, while potassium conductance is rather decreased. In both proximal tubules and MDCK cells, volume regulatory decrease is possibly triggered by leucotrienes, which may be released during cell swelling. Cell volume is altered in a variety of conditions even at isotonic extracellular fluid and cell volume-regulatory mechanisms are likely to participate in regulation of renal transepithelial transport.

Details

Language :
English
ISSN :
1011-6524
Volume :
11
Issue :
3-5
Database :
MEDLINE
Journal :
Renal physiology and biochemistry
Publication Type :
Academic Journal
Accession number :
3074396
Full Text :
https://doi.org/10.1159/000173160