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Applications of excipients in the field of 3D printed pharmaceuticals.
- Source :
-
Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2019 Jun; Vol. 45 (6), pp. 905-913. Date of Electronic Publication: 2019 Mar 20. - Publication Year :
- 2019
-
Abstract
- The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3 D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and thickness of 2 mm, using binder jetting (BJ). The tablets were analyzed by assessing visual and microstructural appearance, friability, hardness, and disintegration time. We found that filling agents with high water solubility (e.g. D-sucrose), binding agents with a high viscosity in solution (e.g. polyethylene glycol 4000) and moistening agent with higher water content can increase the bonding strength and hardness of the 3 D printed tablets and prolonged their disintegration time. This work has demonstrated that the type of excipient and its concentration affects the properties of the 3 D printed tablet. This article may be used as a guide for elucidation of the effects of using conventional tablet excipients in the field of 3 D printed pharmaceuticals. The present work should enable the identification of excipients that satisfy requirements, reduce analysis time, and improve efficiency.
Details
- Language :
- English
- ISSN :
- 1520-5762
- Volume :
- 45
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Drug development and industrial pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 30744433
- Full Text :
- https://doi.org/10.1080/03639045.2019.1576723