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Therapeutic effects of Echinococcus granulosus cystic fluid on allergic airway inflammation.
- Source :
-
Experimental parasitology [Exp Parasitol] 2019 Mar; Vol. 198, pp. 63-70. Date of Electronic Publication: 2019 Feb 11. - Publication Year :
- 2019
-
Abstract
- Previous studies showed that Echinococcus granulosus infection reduces allergic airway inflammation in experimentally infected hosts and the cystic fluid of E. granulosus is known to activate regulatory T (CD4 <superscript>+</superscript> CD25 <superscript>+</superscript> Foxp3 <superscript>+</superscript> T, Treg) cells. To evaluate the effects of cystic fluid of E. granulosus on allergic airway inflammation, we investigated the regulation of the inflammatory reaction by cystic fluid using an allergic airway inflammation animal model. Cystic fluid was administered to C57BL/6 mice seven times every other day, after which allergic airway inflammation was induced using ovalbumin and aluminum. The airway resistance, number of eosinophils and other immune cells in the bronchoalveolar lavage fluid, and levels of Th2 and Th17-related cytokines were significantly reduced by cystic fluid pre-treatment in allergic airway inflammation-induced mice. The number IL-4 <superscript>+</superscript> CD4 <superscript>+</superscript> T cells decreased, the number of Treg cells increased in the lung-draining lymph nodes and spleen of cystic fluid pre-treated mice. In conclusion, E. granulosus-derived cystic fluid may alleviate the Th2 allergic airway inflammatory response via Treg cells. Further studies of the immune regulation of cystic fluid may lead to the development of therapeutic agents for immune disorders.<br /> (Copyright © 2019. Published by Elsevier Inc.)
- Subjects :
- Animals
Bronchoalveolar Lavage Fluid immunology
CD4-Positive T-Lymphocytes drug effects
Cyst Fluid immunology
Cytokines metabolism
Disease Models, Animal
Eosinophils drug effects
Female
Host-Parasite Interactions immunology
Hypersensitivity immunology
Inflammation drug therapy
Interleukin-4 immunology
Lymph Nodes immunology
Mice
Mice, Inbred C57BL
Sheep
Specific Pathogen-Free Organisms
Spleen immunology
T-Lymphocytes, Regulatory drug effects
T-Lymphocytes, Regulatory immunology
Th2 Cells immunology
Airway Resistance drug effects
Bronchoalveolar Lavage Fluid cytology
Cyst Fluid chemistry
Echinococcus granulosus chemistry
Hypersensitivity drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2449
- Volume :
- 198
- Database :
- MEDLINE
- Journal :
- Experimental parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 30763570
- Full Text :
- https://doi.org/10.1016/j.exppara.2019.02.003