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Chitosan nanopolymers: An overview of drug delivery against cancer.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2019 Jun 01; Vol. 130, pp. 727-736. Date of Electronic Publication: 2019 Feb 13. - Publication Year :
- 2019
-
Abstract
- Cancer is becoming a major reason for death troll worldwide due to the difficulty in finding an efficient, cost effective and target specific method of treatment or diagnosis. The variety of cancer therapy used in the present scenario have painful side effects, low effectiveness and high cost, which are some major drawbacks of the available therapies. Apart from the conventional cancer therapy, nanotechnology has grown extremely towards treating cancer. Nanotechnology is a promising area of science focusing on developing target specific drug delivery system for carrying small or large active molecules to diagnose and treat cancer cells. In the field of nanoscience, Chitosan nanopolymers (ChNPs) are been emerging as a potential carrier due to their biodegradability and biocompatibility. The easy modification and versatility in administration route of ChNPs has attracted attention of researchers towards loading chemicals, proteins and gene drugs for target specific therapy of cancer cells. Therefore, the present review deals with the growing concern towards cancer therapy, introduction of ChNPs, mode of action and other strategies employed by researchers till date towards cancer treatment and diagnosis ChNPs.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Acetylation
Animals
Antineoplastic Agents administration & dosage
Biopolymers chemistry
Biopolymers isolation & purification
Chitin chemistry
Chitosan isolation & purification
Combined Modality Therapy
Drug Evaluation, Preclinical
Gene Transfer Techniques
Humans
Molecular Structure
Nanotechnology
Neoplasms diagnosis
Neoplasms drug therapy
Theranostic Nanomedicine
Chitosan chemistry
Drug Carriers chemistry
Drug Delivery Systems
Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 130
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 30771392
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2019.02.060