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Circle of Willis variations in migraine patients with ischemic stroke.
- Source :
-
Brain and behavior [Brain Behav] 2019 Mar; Vol. 9 (3), pp. e01223. Date of Electronic Publication: 2019 Feb 16. - Publication Year :
- 2019
-
Abstract
- Objectives: Migraine is a risk factor for stroke, which might be explained by a higher prevalence in anatomical variants in the circle of Willis (CoW). Here, we compared the presence of CoW variants in patients with stroke with and without migraine.<br />Materials and Methods: Participants were recruited from the prospective Dutch acute Stroke Study. All participants underwent CT angiography on admission. Lifetime migraine history was assessed with a screening questionnaire and confirmed by an interview based on International Classification of Headache Disorders criteria. The CoW was assessed for incompleteness/hypoplasia (any segment <1 mm), for anterior cerebral artery asymmetry (difference > 1/3), and for posterior communicating artery (Pcom) dominance (Pcom-P1 difference > 1/3). Odds ratios with adjustments for age and sex (aOR) were calculated with logistic regression.<br />Results: We included 646 participants with stroke, of whom 52 had a history of migraine. Of these, 45 (87%) had an incomplete or hypoplastic CoW versus 506 (85%) of the 594 participants without migraine (aOR: 1.47; 95% CI: 0.63-3.44). There were no differences between participants with and without migraine in variations of the anterior or posterior CoW, anterior cerebral artery asymmetry (aOR: 0.86; 95% CI: 0.43-1.74), or Pcom dominance (aOR: 0.64; 95% CI: 0.32-1.30). There were no differences in CoW variations between migraine patients with or without aura.<br />Conclusion: We found no significant difference in the completeness of the CoW in acute stroke patients with migraine compared to those without.<br /> (© 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Analysis of Variance
Brain blood supply
Computed Tomography Angiography methods
Female
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Risk Factors
Brain Ischemia diagnosis
Brain Ischemia physiopathology
Circle of Willis diagnostic imaging
Circle of Willis pathology
Migraine Disorders complications
Migraine Disorders physiopathology
Stroke complications
Stroke physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 2162-3279
- Volume :
- 9
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Brain and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 30772952
- Full Text :
- https://doi.org/10.1002/brb3.1223