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Kidney Transplant in a Patient With Factor VII Deficiency: Case Report.
- Source :
-
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2019 Jan; Vol. 17 (Suppl 1), pp. 142-144. - Publication Year :
- 2019
-
Abstract
- Organ transplant in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Inherited factor VII deficiency is the most common of the rare bleeding disorders, with a wide set of hemorrhagic features. Although a kidney allograft is the most frequent type of solid-organ transplant, it is rarely performed in individuals with congenital hemorrhagic disorders. Here, we highlight the course of a patient with coagulation factor VII deficiency who underwent successful kidney transplant without significant coagulopathy. Our patient was a 19-year-old man with end-stage kidney disease and congenital coagulation factor VII deficiency. Perioperative bleeding was successfully prevented by administration of recombinant factor VII, confirming its safety in solid-organ transplants. Success requires evaluation of doses and therapeutic schedules, as well as a multidisciplinary approach.
- Subjects :
- Blood Coagulation drug effects
Drug Monitoring methods
Factor VII Deficiency blood
Factor VII Deficiency complications
Factor VII Deficiency diagnosis
Graft Survival drug effects
Humans
Immunosuppressive Agents administration & dosage
International Normalized Ratio
Kidney Failure, Chronic complications
Kidney Failure, Chronic diagnosis
Male
Recombinant Proteins administration & dosage
Treatment Outcome
Young Adult
Blood Loss, Surgical prevention & control
Coagulants administration & dosage
Factor VII Deficiency drug therapy
Factor VIIa administration & dosage
Kidney Failure, Chronic therapy
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 2146-8427
- Volume :
- 17
- Issue :
- Suppl 1
- Database :
- MEDLINE
- Journal :
- Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 30777540
- Full Text :
- https://doi.org/10.6002/ect.MESOT2018.P9