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Kidney Transplant in a Patient With Factor VII Deficiency: Case Report.

Authors :
Abdeltawab K
Yagan J
Megahed M
Zahab MA
Gheith OA
Rida S
Nair P
Mahmoud T
Maher AM
Al-Mohareb S
Mohamed M
Al-Otaibi T
Source :
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation [Exp Clin Transplant] 2019 Jan; Vol. 17 (Suppl 1), pp. 142-144.
Publication Year :
2019

Abstract

Organ transplant in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Inherited factor VII deficiency is the most common of the rare bleeding disorders, with a wide set of hemorrhagic features. Although a kidney allograft is the most frequent type of solid-organ transplant, it is rarely performed in individuals with congenital hemorrhagic disorders. Here, we highlight the course of a patient with coagulation factor VII deficiency who underwent successful kidney transplant without significant coagulopathy. Our patient was a 19-year-old man with end-stage kidney disease and congenital coagulation factor VII deficiency. Perioperative bleeding was successfully prevented by administration of recombinant factor VII, confirming its safety in solid-organ transplants. Success requires evaluation of doses and therapeutic schedules, as well as a multidisciplinary approach.

Details

Language :
English
ISSN :
2146-8427
Volume :
17
Issue :
Suppl 1
Database :
MEDLINE
Journal :
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
Publication Type :
Academic Journal
Accession number :
30777540
Full Text :
https://doi.org/10.6002/ect.MESOT2018.P9