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JAK3 Variant, Immune Signatures, DNA Methylation, and Social Determinants Linked to Survival Racial Disparities in Head and Neck Cancer Patients.
- Source :
-
Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2019 Apr; Vol. 12 (4), pp. 255-270. Date of Electronic Publication: 2019 Feb 18. - Publication Year :
- 2019
-
Abstract
- To inform novel personalized medicine approaches for race and socioeconomic disparities in head and neck cancer, we examined germline and somatic mutations, immune signatures, and epigenetic alterations linked to neighborhood determinants of health in Black and non-Latino White (NLW) patients with head and neck cancer. Cox proportional hazards revealed that Black patients with squamous cell carcinoma of head and neck (HNSCC) with PAX5 ( P = 0.06) and PAX1 ( P = 0.017) promoter methylation had worse survival than NLW patients, after controlling for education, zipcode, and tumor-node-metastasis stage ( n = 118). We also found that promoter methylation of PAX1 and P AX5 ( n = 78), was correlated with neighborhood characteristics at the zip-code level ( P < 0.05). Analyses also showed differences in the frequency of TP53 mutations ( n = 32) and tumor-infiltrating lymphocyte (TIL) counts ( n = 24), and the presence of a specific C → A germline mutation in JAK3 , chr19:17954215 (protein P132T), in Black patients with HNSCC ( n = 73; P < 0.05), when compared with NLW ( n = 37) patients. TIL counts are associated ( P = 0.035) with long-term (>5 years), when compared with short-term survival (<2 years). We show bio-social determinants of health associated with survival in Black patients with HNSCC, which together with racial differences shown in germline mutations, somatic mutations, and TIL counts, suggests that contextual factors may significantly inform precision oncology services for diverse populations.<br /> (©2019 American Association for Cancer Research.)
- Subjects :
- Adult
Black or African American statistics & numerical data
Biomarkers, Tumor analysis
Case-Control Studies
Female
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms ethnology
Head and Neck Neoplasms genetics
Head and Neck Neoplasms immunology
Humans
Male
Middle Aged
Prognosis
Squamous Cell Carcinoma of Head and Neck ethnology
Squamous Cell Carcinoma of Head and Neck genetics
Squamous Cell Carcinoma of Head and Neck immunology
Squamous Cell Carcinoma of Head and Neck mortality
Survival Rate
Tumor Suppressor Protein p53 genetics
White People statistics & numerical data
DNA Methylation
Germ-Line Mutation
Head and Neck Neoplasms mortality
Health Status Disparities
Janus Kinase 3 genetics
Lymphocytes, Tumor-Infiltrating immunology
Social Determinants of Health
Subjects
Details
- Language :
- English
- ISSN :
- 1940-6215
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer prevention research (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 30777857
- Full Text :
- https://doi.org/10.1158/1940-6207.CAPR-17-0356