Back to Search
Start Over
Expression and function of macrophage-inducible C-type lectin (Mincle) in inflammation driven parturition in fetal membranes and myometrium.
- Source :
-
Clinical and experimental immunology [Clin Exp Immunol] 2019 Jul; Vol. 197 (1), pp. 95-110. Date of Electronic Publication: 2019 Mar 13. - Publication Year :
- 2019
-
Abstract
- The pivotal role of inflammatory processes in human parturition is well known, but not completely understood. We have performed a study to examine the role of macrophage-inducible C-type lectin (Mincle) in inflammation-associated parturition. Using human samples, we show that spontaneous labour is associated with up-regulated Mincle expression in the myometrium and fetal membranes. Mincle expression was also increased in fetal membranes and myometrium in the presence of pro-labour mediators, the proinflammatory cytokines interleukin (IL)-1B and tumour necrosis factor (TNF), and Toll-like receptor (TLR) ligands fsl-1, poly(I:C), lipopolysaccharide (LPS) and flagellin. These clinical studies are supported by mouse studies, where an inflammatory challenge in a mouse model of preterm birth increased Mincle expression in the uterus. Importantly, elimination of Mincle decreased the effectiveness of proinflammatory cytokines and TLR ligands to induce the expression of pro-labour mediators; namely, proinflammatory cytokines and chemokines, contraction-associated proteins and prostaglandins, and extracellular matrix remodelling enzymes, matrix metalloproteinases. The data presented in this study suggest that Mincle is required when inflammatory activation precipitates parturition.<br /> (© 2019 British Society for Immunology.)
- Subjects :
- Animals
Chemokines metabolism
Cytokines metabolism
Extracellular Matrix enzymology
Extraembryonic Membranes cytology
Extraembryonic Membranes metabolism
Female
Gene Knockdown Techniques
Humans
In Vitro Techniques
Inflammation Mediators metabolism
Lectins, C-Type antagonists & inhibitors
Lectins, C-Type genetics
Membrane Proteins genetics
Membrane Proteins immunology
Mice
Myometrium cytology
Myometrium metabolism
Parturition genetics
Parturition metabolism
Pregnancy
RNA, Messenger genetics
RNA, Messenger metabolism
Receptors, Immunologic antagonists & inhibitors
Receptors, Immunologic genetics
Receptors, Pattern Recognition metabolism
Up-Regulation
Extraembryonic Membranes immunology
Lectins, C-Type immunology
Myometrium immunology
Parturition immunology
Receptors, Immunologic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2249
- Volume :
- 197
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Clinical and experimental immunology
- Publication Type :
- Academic Journal
- Accession number :
- 30793298
- Full Text :
- https://doi.org/10.1111/cei.13281