Back to Search
Start Over
Wearable Ultrasound Improves Motor Function in an MPTP Mouse Model of Parkinson's Disease.
- Source :
-
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2019 Nov; Vol. 66 (11), pp. 3006-3013. Date of Electronic Publication: 2019 Feb 15. - Publication Year :
- 2019
-
Abstract
- Objective: Low-frequency low-intensity pulsed ultrasound (LIPUS) has emerged as a non-invasive neuromodulation tool. The aim of this study is to examine whether LIPUS stimulation of the motor cortex can improve parkinsonian motor deficit in a mouse model induced by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).<br />Methods: Acute Parkinson's disease (PD) mouse model is built by injection of MPTP (20 mg/kg) every 4 h in a total of four doses in one day. Mice are randomized into control, MPTP, sham-LIPUS+MPTP, and LIPUS+MPTP group. For LIPUS+MPTP group, 7 days of LIPUS (800 kHz, 10% duty cycle, 100-Hz pulse repetition frequency, 40 min/day) is delivered to the motor cortex. An open field test (OFT) is conducted on day 4 and a pole test on day 5, respectively. Striatal total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-PX) are measured on day 8. The safety of LIPUS is verified using Hematoxylin and esosin (HE) staining and Nissl staining.<br />Results: LIPUS treatment improves rearing number in the OFT on day 4 (n = 8, p = 0.037) and locomotor activity in the pole test on day 5 (n = 8, p = 0.007) compared with the sham-LIPUS+MPTP group. Moreover, LIPUS increases T-SOD (n = 7, p = 0.006) and GSH-PX (n = 7, p = 0.030) compared with the sham-LIPUS+MPTP group. In addition, HE and Nissl staining shows no brain tissue injury induced by LIPUS.<br />Conclusion: These findings demonstrate that LIPUS may have neuromodulation effects in PD mice.<br />Significance: LIPUS may provide a novel neuromodulation tool for PD treatment.
- Subjects :
- Animals
Behavior, Animal radiation effects
Disease Models, Animal
Equipment Design
Male
Mice
Mice, Inbred C57BL
Motor Cortex pathology
Motor Cortex radiation effects
Parkinson Disease physiopathology
Transducers
Motor Activity radiation effects
Parkinson Disease therapy
Ultrasonic Therapy adverse effects
Ultrasonic Therapy instrumentation
Ultrasonic Therapy methods
Wearable Electronic Devices
Subjects
Details
- Language :
- English
- ISSN :
- 1558-2531
- Volume :
- 66
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- IEEE transactions on bio-medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 30794160
- Full Text :
- https://doi.org/10.1109/TBME.2019.2899631