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Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo.

Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo.

Authors :
Ahn JH
Woo JH
Rho JR
Choi JH
Source :
Marine drugs [Mar Drugs] 2019 Feb 21; Vol. 17 (2). Date of Electronic Publication: 2019 Feb 21.
Publication Year :
2019

Abstract

Gukulenin A is a bis-tropolone tetraterpenoid isolated from the marine sponge Phorbas gukhulensis . In this study, we examined the anticancer activities of gukulenin A in ovarian cancer cell lines (A2780, SKOV3, OVCAR-3, and TOV-21G) and in an ovarian cancer mouse model generated by injecting A2780 cells. We found that gukulenin A suppressed tumor growth in A2780-bearing mice. Gukulenin A markedly inhibited cell viability in four ovarian cancer cell lines, including the A2780 cell line. Gukulenin A treatment increased the fraction of cells accumulated at the sub G1 phase in a dose-dependent manner and the population of annexin V-positive cells, suggesting that gukulenin A induces apoptotic cell death in ovarian cancer cells. In addition, gukulenin A triggered the activation of caspase-3, -8, and -9, and caspase inhibitors attenuated gukulenin A-induced A2780 cell death. The results suggest that gukulenin A may be a potential therapeutic agent for ovarian cancer.

Details

Language :
English
ISSN :
1660-3397
Volume :
17
Issue :
2
Database :
MEDLINE
Journal :
Marine drugs
Publication Type :
Academic Journal
Accession number :
30795557
Full Text :
https://doi.org/10.3390/md17020126