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Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo.
Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo.
- Source :
-
Marine drugs [Mar Drugs] 2019 Feb 21; Vol. 17 (2). Date of Electronic Publication: 2019 Feb 21. - Publication Year :
- 2019
-
Abstract
- Gukulenin A is a bis-tropolone tetraterpenoid isolated from the marine sponge Phorbas gukhulensis . In this study, we examined the anticancer activities of gukulenin A in ovarian cancer cell lines (A2780, SKOV3, OVCAR-3, and TOV-21G) and in an ovarian cancer mouse model generated by injecting A2780 cells. We found that gukulenin A suppressed tumor growth in A2780-bearing mice. Gukulenin A markedly inhibited cell viability in four ovarian cancer cell lines, including the A2780 cell line. Gukulenin A treatment increased the fraction of cells accumulated at the sub G1 phase in a dose-dependent manner and the population of annexin V-positive cells, suggesting that gukulenin A induces apoptotic cell death in ovarian cancer cells. In addition, gukulenin A triggered the activation of caspase-3, -8, and -9, and caspase inhibitors attenuated gukulenin A-induced A2780 cell death. The results suggest that gukulenin A may be a potential therapeutic agent for ovarian cancer.
- Subjects :
- Animals
Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
Apoptosis drug effects
Caspase 3 metabolism
Caspase 8 metabolism
Caspase 9 metabolism
Cell Cycle drug effects
Cell Line, Tumor
Female
Humans
Mice
Mice, Inbred BALB C
Mice, Nude
Ovarian Neoplasms metabolism
Ovarian Neoplasms pathology
Random Allocation
Terpenes isolation & purification
Xenograft Model Antitumor Assays
Ovarian Neoplasms drug therapy
Porifera chemistry
Terpenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 30795557
- Full Text :
- https://doi.org/10.3390/md17020126