Influence of ERAP1 and ERAP2 gene polymorphisms on disease susceptibility in different populations.

Authors :: Yao Y
Liu N
Zhou Z
Shi L
Source :: Human immunology [Hum Immunol] 2019 May; Vol. 80 (5), pp. 325-334. Date of Electronic Publication: 2019 Feb 21.
Publication Year :: 2019
Abstract: The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens. Association studies have shown that genetic variations in ERAP1 and ERAP2 genes increase susceptibility to autoimmune diseases, infectious diseases, and cancers. Both ERAP1 and ERAP2 genes exhibit diverse polymorphisms in different populations, which may influence their susceptibly to the aforementioned diseases. In this article, we review the distribution of ERAP1 and ERAP2 gene polymorphisms in various populations; discuss the risk or protective influence of these gene polymorphisms in autoimmune diseases, infectious diseases, and cancers; and highlight how ERAP genetic variations can influence disease associations.<br /> (Copyright © 2019. Published by Elsevier Inc.)

Subjects :: Aminopeptidases chemistry
Aminopeptidases metabolism
Antigen Presentation immunology
Autoimmune Diseases etiology
Autoimmune Diseases metabolism
Evolution, Molecular
Genetics, Population
Genotype
Histocompatibility Antigens Class I immunology
Humans
Minor Histocompatibility Antigens chemistry
Minor Histocompatibility Antigens metabolism
Racial Groups genetics
Structure-Activity Relationship
Aminopeptidases genetics
Genetic Predisposition to Disease
Minor Histocompatibility Antigens genetics
Polymorphism, Single Nucleotide

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