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Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party.
- Source :
-
Bone marrow transplantation [Bone Marrow Transplant] 2019 Oct; Vol. 54 (10), pp. 1625-1631. Date of Electronic Publication: 2019 Feb 25. - Publication Year :
- 2019
-
Abstract
- The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24-66). Underlying diagnoses were diffuse large B cell lymphoma in 47%, Hodgkin lymphoma in 24%, Burkitt lymphoma in 18%, and plasmablastic lymphoma in 7% of patients. Disease status at autoHCT was complete remission in 44%, partial remission (PR) in 38%, and less than PR in 18% of the patients. With a median follow-up of 4 years, 3-year non-relapse mortality, incidence of relapse, progression-free survival (PFS) and overall survival (OS) were 10%, 27%, 63% and 66%, respectively. By multivariate analysis, disease status less than PR but not CD4+ cell count at the time of autoHCT was a significant predictor of unfavorable PFS and OS. In conclusion, in the era of cART and chemoimmunotherapy, the outcome of autoHCT for HIV-related lymphoma is driven by lymphoma-dependent risk factors rather than by characteristics of the HIV infection.
- Subjects :
- Adult
Aged
Anti-Retroviral Agents pharmacology
Female
Humans
Male
Middle Aged
Retrospective Studies
Rituximab pharmacology
Young Adult
Anti-Retroviral Agents therapeutic use
HIV Infections complications
Lymphoma drug therapy
Lymphoma therapy
Rituximab therapeutic use
Transplantation, Autologous methods
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5365
- Volume :
- 54
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Bone marrow transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 30804486
- Full Text :
- https://doi.org/10.1038/s41409-019-0480-x