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Phytochemistry and antiplasmodial activity of Xylopia sericea leaves.

Phytochemistry and antiplasmodial activity of Xylopia sericea leaves.

Authors :
Gontijo DC
Nascimento MFAD
Brandão GC
Oliveira AB
Source :
Natural product research [Nat Prod Res] 2020 Dec; Vol. 34 (24), pp. 3526-3530. Date of Electronic Publication: 2019 Feb 27.
Publication Year :
2020

Abstract

Aiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass spectrometry, and were evaluated against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity to HepG2 cells. Low growth inhibition of P. falciparum as well as low cytotoxicity to HepG2 cells were observed for the essential oil. The leaves dichloromethane extract showed moderate growth inhibition of P. falciparum and low cytotoxicity to HepG2 cells. Bioguided chromatographic fractionation of this extract led to fractions with increased antiplasmodial activity from which liriodenine (IC <subscript>50</subscript> 6.1 ± 0.1 μg/mL, CC <subscript>50</subscript> > 1000.0 μg/mL, SI > 164), an aporphine alkaloid, and an acetogenin-rich fraction containing mainly isomers of annomontacin and 4-deoxy-annomontacin (IC <subscript>50</subscript> 22.7 ± 1.9 µg/mL, CC <subscript>50</subscript> 336.1 ± 15.5 µg/mL, SI = 15) might be highlighted for their antiplasmodial activity.

Details

Language :
English
ISSN :
1478-6427
Volume :
34
Issue :
24
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
30810362
Full Text :
https://doi.org/10.1080/14786419.2019.1577838