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Phytochemistry and antiplasmodial activity of Xylopia sericea leaves.
Phytochemistry and antiplasmodial activity of Xylopia sericea leaves.
- Source :
-
Natural product research [Nat Prod Res] 2020 Dec; Vol. 34 (24), pp. 3526-3530. Date of Electronic Publication: 2019 Feb 27. - Publication Year :
- 2020
-
Abstract
- Aiming to investigate the antiplasmodial activity and the phytochemical composition of Xylopia sericea leaves, the essential oil and dichloromethane extract were analyzed by gas and liquid chromatography, respectively, both of them coupled to mass spectrometry, and were evaluated against the chloroquine-resistant Plasmodium falciparum strain (W2) and for cytotoxicity to HepG2 cells. Low growth inhibition of P. falciparum as well as low cytotoxicity to HepG2 cells were observed for the essential oil. The leaves dichloromethane extract showed moderate growth inhibition of P. falciparum and low cytotoxicity to HepG2 cells. Bioguided chromatographic fractionation of this extract led to fractions with increased antiplasmodial activity from which liriodenine (IC <subscript>50</subscript> 6.1 ± 0.1 μg/mL, CC <subscript>50</subscript> > 1000.0 μg/mL, SI > 164), an aporphine alkaloid, and an acetogenin-rich fraction containing mainly isomers of annomontacin and 4-deoxy-annomontacin (IC <subscript>50</subscript> 22.7 ± 1.9 µg/mL, CC <subscript>50</subscript> 336.1 ± 15.5 µg/mL, SI = 15) might be highlighted for their antiplasmodial activity.
- Subjects :
- Animals
Antimalarials chemistry
Antimalarials toxicity
Aporphines chemistry
Aporphines pharmacology
Chloroquine pharmacology
Chromatography, Gas
Chromatography, Liquid
Drug Evaluation, Preclinical
Drug Resistance, Microbial
Furans pharmacology
Hep G2 Cells
Humans
Lactones pharmacology
Oils, Volatile chemistry
Plant Extracts chemistry
Plant Extracts pharmacology
Plant Leaves chemistry
Antimalarials pharmacology
Plasmodium falciparum drug effects
Xylopia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 34
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 30810362
- Full Text :
- https://doi.org/10.1080/14786419.2019.1577838